Almeida et al., Kidney Int 2006
(Endotoxemia) :
Renin and angiotensinogen protein levels were not affected by LPS according to Western blot analysis
Takano et al., Biol Pharm Bull 1993
(Liver Neoplasms, Experimental) :
To understand the mechanisms responsible for lipopolysaccharide (LPS) induced enhancement of angiotensinogen synthesis in the liver, studies were carried out in rats with repeated doses of LPS ... These results indicate that LPS induced enhancement of angiotensinogen synthesis in the liver is desensitized in rats after repetitive LPS exposure, presumably by the failure of LPS induced IL-6 production