Gene interactions and pathways from curated databases and text-mining

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IL6 — TIMP2

Text-mined interactions from Literome

Wang et al., Cell Signal 2005 (MAP Kinase Signaling System...) : Differential activation of the MEK/ERK and PI3K/AKT pathways that result in differential secretion IL-6, IL-8, TIMP-2 and VEGF were seen contingent on the cell type examined ; VEGF and TIMP-2 expression in PC3 cells are dependent on AKT activation and ERK activation in LNCaP and LNCaP C4-2B cells leads to IL-6 or IL-8 secretion
Okumura et al., J Cardiovasc Electrophysiol 2011 (Atrial Fibrillation...) : Overall, hs-CRP, IL-6 , ANP, and BNP levels decreased, and MMP-2, TIMP-2 , and ICTP levels increased 2 months after ablation
Zafarullah et al., J Cell Biochem 1996 (Osteoarthritis) : IL-1 beta, IL-6 and TGF-beta did not affect TIMP-2 expression but TGF-beta induced TIMP-1 mRNA in human OA chondrocytes