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IL6 — TIMP2
Text-mined interactions from Literome
Wang et al., Cell Signal 2005
(MAP Kinase Signaling System...) :
Differential activation of the MEK/ERK and PI3K/AKT pathways that result in differential secretion IL-6, IL-8, TIMP-2 and VEGF were seen contingent on the cell type examined ; VEGF and
TIMP-2 expression in PC3 cells are dependent on AKT activation and ERK activation in LNCaP and LNCaP C4-2B cells
leads to
IL-6 or IL-8 secretion
Okumura et al., J Cardiovasc Electrophysiol 2011
(Atrial Fibrillation...) :
Overall, hs-CRP,
IL-6 , ANP, and BNP levels decreased, and MMP-2,
TIMP-2 , and ICTP levels
increased 2 months after ablation
Zafarullah et al., J Cell Biochem 1996
(Osteoarthritis) :
IL-1 beta,
IL-6 and TGF-beta did not
affect TIMP-2 expression but TGF-beta induced TIMP-1 mRNA in human OA chondrocytes