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IL3 — IL6

Text-mined interactions from Literome

Shinoda et al., Cell Signal 1999 : C2-ceramide did not affect the IL-6 synthesis induced by interleukin-1
Michl et al., J Neuroendocrinol 2000 : Coincubation with indometacin completely abolished the stimulatory effect of IL-6 but had no effect on IL-3 stimulated cortisol secretion
Albanesi et al., J Invest Dermatol 2000 (Dermatitis, Allergic Contact...) : In addition, interleukin-17 stimulated the release of growth regulated oncogene-alpha, granulocyte-macrophage colony stimulating factor, and interleukin-6 , with synergistic or additive effects when used together with interferon-gamma or interleukin-4
Lee et al., Arch Pharm Res 2000 : High level of macrophage-colony stimulating factor ( M-CSF ) and interleukin (IL)-6 was detected in the TFGD-culture supernatant, whereas granulocyte/macrophage-colony stimulating factor ( GM-CSF ), IL-3 , IL-4, IL-5, IL-13, or interferon (IFN)-gamma was undetectable
Yamaguchi et al., Stem Cells 1996 : The purified MPF showed Meg-POT activity almost equal to human ( Hu ) interleukin 6 (IL-6) in the presence of murine IL-3 in a colony forming assay with mouse bone marrow cells
Yun et al., Life Sci 2000 (Leukemia, Erythroblastic, Acute...) : Genistin showed inhibitory effects on IL-5 and IL-3 bioactivities, but did not inhibit GM-CSF and IL-6 bioactivities
Ishikawa et al., Jpn J Vet Res 2001 : Brain interleukin-1 is involved in blood interleukin-6 response to immobilization stress in rats
Zirngibl et al., Mol Cell Biol 2002 : Bone marrow derived Fps/Fes-null macrophages showed no defects in granulocyte-macrophage colony stimulating factor-, interleukin 6 (IL-6)-, or IL-3 induced activation of signal transducer and activator of transcription 3 ( Stat3 ) and Stat5A or LPS induced degradation of I kappa B or activation of p38, Jnk, Erk, or Akt
Andoh et al., Biochim Biophys Acta 2002 : In human pancreatic myofibroblasts, interleukin (IL)-17 markedly enhances tumor necrosis factor (TNF)-alpha induced IL-6 secretion through the induction of IL-6 mRNA stabilization
Okada et al., Blood 1992 : Lin-c-kit+Sca-1+ cells formed no colonies in the presence of stem cell factor (SCF) or interleukin-6 (IL-6) , and only 10 % of them formed colonies in the presence of IL-3
Yamamoto et al., Arthritis Rheum 2003 (Arthritis, Experimental...) : The effects of RasDN overexpression on cellular proliferation, interleukin-1 (IL-1) induced activation of mitogen activated protein kinases ( extracellular signal regulated kinase [ ERK ], p38, c-Jun N-terminal kinase [ JNK ] ), and IL-6 production by synovial cells were analyzed
Planck et al., Invest Ophthalmol Vis Sci 1992 : Retinal pigment epithelial cells secrete interleukin-6 in response to interleukin-1
Shimizu et al., Arch Oral Biol 1992 : Stimulation by interleukin-1 of interleukin-6 production by human periodontal ligament cells
Nishitai et al., J Biol Chem 2004 : Instead, interleukin-1 beta (IL-1 beta) induced IL-6 gene expression was greatly suppressed in sek1 ( -/- ) mkk7 ( -/- ) fibroblasts
Lee et al., Blood 2004 (Bone Resorption...) : IL-3 stimulated the growth of interleukin-6 (IL-6) dependent and IL-6 independent myeloma cells in the absence of IL-6, even though IL-3 did not induce IL-6 expression by myeloma cells
Saito et al., Mech Ageing Dev 2003 (Endotoxemia...) : The stress mediated induction of interleukin-1beta, interleukin-6 , and interleukin-10 ( IL-1beta, IL-6, and IL-10 ) in the circulating blood tended to be higher with aging in both CLP and LPS models, and in particular, the induction of IL-6 was significantly augmented with aging
Silfverswärd et al., J Orthop Res 2004 : Interleukin-4 and interleukin-13 potentiate interleukin-1 induced secretion of interleukin-6 in human osteoblast-like cells
Nesbitt et al., Mol Biol Cell 1992 (Inflammation) : We employed ribonuclease protection assays to measure the expression of IL-6-R and gp130 mRNA in primary rat hepatocytes in response to IL-6, interleukin-1 , dexamethasone, and combinations thereof
Méndez-Dávila et al., J Endocrinol Invest 2004 (Osteoporosis) : We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and interleukin-1 stimulated interleukin (IL)-6 , transforming growth factor-beta1 ( TGF-beta1 ) and insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Matsuzaki et al., Cancer Sci 2006 : We have demonstrated previously that the Th1-cytokine conditioned bone marrow derived dendritic cell ( BMDC ) subset BMDC1 ( generated in the presence of granulocyte-macrophage colony stimulating factor [GM-CSF ] + interleukin [ IL]-3 + interferon [ IFN]-gamma+ IL-12 ) induces a much stronger type 1 immune response than BMDC0 ( GM-CSF + IL-3 )
Okada et al., Exp Hematol 1991 : However, IL-6 but not G-CSF acted synergistically on enriched hemopoietic stem cells in the presence of IL-3
Hashmi et al., Coron Artery Dis 2006 (Angina, Unstable) : Role of interleukin-17 and interleukin-17 induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease
Lindemann et al., Eur Cytokine Netw 1991 (Neoplasms) : These results indicate that rh IL-3 also augments the acute phase response in vivo and contributes to increased synthesis of IgM and that induction of endogenous IL-6 is involved in these events
Szabo et al., J Clin Immunol 1991 (Burns...) : Furthermore, interleukin-4 dependent downregulation of monocyte interleukin-6 expression is confirmed at both the supernatant and the mRNA levels
Miyashita et al., Leuk Res 1991 : IL-3 stimulated the production of IL-6 from a bone marrow-adherent cell population, macrophages and from hemopoietic supportive stromal cell lines ... In contrast, stimulation with IL-6 of all the cell populations studied in the present experiments did not induce IL-3 production ... These results indicate a hierarchical network in the regulation of interleukin production, and existence of a positive feedback mechanism ; IL-3 induces IL-6 production which in turn stimulates stem cells into cycle and induces stem cells to respond to IL-3
Burch et al., Agents Actions 1991 (Wounds and Injuries) : Basal interleukin-1 and 6 release were not affected by sucralfate, but the agent enhanced interleukin-1 stimulated interleukin-6 release from fibroblasts
Dy et al., Exp Hematol 1991 : Murine interleukin 3 (IL-3) induces a strong, concomitant increase in histamine, interleukin 6 (IL-6) , and interleukin 4 (IL-4) synthesis by progenitor enriched bone marrow cell populations, whereas interleukin 2 (IL-2) or interferon-gamma (IFN-gamma) are undetectable
Kondo et al., Int Immunol 2008 (Hyperplasia...) : Basophils, comprising IL-18Ralpha ( + ) cells ( 14.2 % ) and IL-33Ralpha ( + ) cells ( 34.6 % ), and mast cells, comprising IL-18Ralpha ( + ) cells ( 2.0 % ) and IL-33Ralpha ( + ) cells ( 95.6 % ), produce IL-4, IL-6 , IL-13, granulocyte macrophage colony stimulating factor ( GM-CSF ) and chemokines ( RANTES, MIP-1alpha, MIP-1beta and MCP-1 ), upon stimulation with IL-18 and/or IL-33 in the presence of IL-3
Krogh Rasmussen et al., Acta Endocrinol (Copenh) 1991 : In conclusion, it is unlikely that interleukin 6 by itself mediates the biological effects of interleukin 1 on human thyroid cells
Layh-Schmitt et al., Curr Opin Rheumatol 2008 (Spondylarthropathies) : In mice, transforming growth factor-beta and interleukin-6 are critical, whereas interleukin-23 is more important at later stages promoting interleukin-17 production
Cohen et al., Immunol Lett 1991 : We have studied the production of interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor (TNF) by mouse peritoneal macrophages triggered by lipopolysaccharide (LPS) in the presence or absence of IL-3 ... Interleukin-3 at the concentration used ( i.e., 100 U/ml ) did not induce the production of any cytokines, whereas it enhanced significantly the secretion of IL-1, IL-6 and TNF by LPS stimulated macrophages
Baigrie et al., Lymphokine Cytokine Res 1991 (Aortic Aneurysm...) : A sequential interleukin-1 beta and interleukin-6 response has not been noted before in vivo, and would seem to provide evidence supporting the in vitro observation that interleukin-1 induces interleukin-6 synthesis and release
Braquet et al., Int Arch Allergy Appl Immunol 1991 : We compared the effects of platelet activating factor (PAF), interleukin-1 beta (IL-1 beta) and polyriboinositic-polyribocytidylic acid ( poly-I:C ) on IL-6 production by confluent L929 mouse fibroblasts
Brühl et al., Arthritis Rheum 2009 (Arthritis, Experimental) : In studies of the regulation of IL-3 expression in CD4+ T cells, IL-6 and IL-4 suppressed the release of IL-3 by activated CD4+ T cells, whereas lipopolysaccharide and CpG DNA up-regulated IL-3 secretion in activated CD4+ T cells by acting on costimulatory cells
Han et al., Int J Hematol 1991 (Hematologic Diseases) : Critical analysis of these data indicates that : ( i ) megakaryocytopoiesis is a complex, multiple-stage cellular and biologic process ; ( ii ) the survival, proliferation and differentiation of progenitor cells into immature megakaryocytes are regulated mainly by interleukin-3 , granulocyte-macrophage colony stimulating factor and an as yet uncharacterized megakaryocyte colony stimulating factor, and the maturation of immature megakaryocytes to produce platelets is regulated primarily by interleukin-6 and thrombopoietin; (iii) optimal megakaryocyte development needs adequate interactions of several growth factors with target cell population and hematopoietic microenvironment ; ( iv ) megakaryocytopoietic inhibition is controlled essentially by megakaryocyte-platelet products such as transforming growth factor-beta, and platelet factor 4 and its related proteins ; interferon-alpha and -gamma also are able to play an inhibitory role ; and ( v ) expansion or decrease of either normal or neoplastic megakaryocyte progenitor cells, change of platelet mass and abnormalities of growth factor levels in hematopoietic tissue might result in an abnormal megakaryocytopoiesis
Schneider et al., Blood 1991 : Characterization of murine hematopoietic progenitor subsets involved in interleukin-3 induced interleukin-6 production ... These procedures have allowed us to ascribe the following features to the cells mainly responsible for IL-3 induced IL-6 production : ( 1 ) they possess a low density and a relatively high forward and perpendicular light scatter ( FLS/PLS ) ; ( 2 ) they are characterized by a high rhodamine ( Rh ) retention ; and ( 3 ) their enrichment in various subpopulations is similar to that obtained for progenitors forming colonies in the methylcellulose assay colony forming units ( CFU-C )
Zhang et al., Beijing Da Xue Xue Bao 2010 (Chlamydia Infections...) : [ Early production of interleukin-17 in airway upon Chlamydia trachomatis infection increases the local secretion of IL-6 and MIP-2 ]
Nakagawa et al., J Immunol 2011 : Recombinant Sema4B significantly inhibited IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 , papain, and FceRI cross linking
Kim et al., Naunyn Schmiedebergs Arch Pharmacol 2011 : Grape seed proanthocyanidin extract inhibits interleukin-17 induced interleukin-6 production via MAPK pathway in human pulmonary epithelial cells
Tanabe et al., Journal of neuroinflammation 2011 : Midazolam suppresses interleukin-1ß induced interleukin-6 release from rat glial cells
Nakamura et al., Eur J Oral Sci 2011 (Gingivitis) : Involvement of angiotensin II type 1 receptors in interleukin-1ß induced interleukin-6 production in human gingival fibroblasts
Zhang et al., Mol Cell Biol 1990 (Chromosome Deletion) : Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence
Libert et al., Eur J Immunol 1990 : Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice
Koike et al., Blood 1990 : Delayed addition experiments and replating experiments of blast cell colonies showed that megakaryocytic progenitors are supported by IL-3 in the early stage of the development but require IL-6 for their subsequent proliferation and differentiation
Cavaillon et al., Cell Immunol 1990 : Induction of interleukin-3 by interleukin-1 in the absence of other exogenous stimuli
Kuroyanagi et al., Biochimie 2013 : ( - ) -Epigallocatechin gallate amplifies interleukin-1 stimulated interleukin-6 synthesis in osteoblast-like MC3T3-E1 cells
Bunning et al., Biochem Biophys Res Commun 1990 : Independent induction of interleukin 6 and prostaglandin E2 by interleukin 1 in human articular chondrocytes
Shalaby et al., Clin Immunol Immunopathol 1989 (Shock, Septic) : Endotoxin, tumor necrosis factor-alpha and interleukin 1 induce interleukin 6 production in vivo
Bodine et al., Proc Natl Acad Sci U S A 1989 : Stem cell function was measured by competitive repopulation ; IL-3 was required , and IL-3 and IL-6 appear to act synergistically to enhance stem cell recovery from these cultures
Helle et al., Eur J Immunol 1988 : Interleukin 6 is involved in interleukin 1-induced activities
Zimecki et al., Arch Immunol Ther Exp (Warsz) 1994 : Interleukin 6 produced by activated thymocytes induces interleukin 1 production by macrophages
Yanai et al., Leuk Res 1994 (Anemia) : IL-3 induced the production of IL-6 , GM-CSF and G-CSF from the bone marrow cells of +/+ mice
Rameshwar et al., J Immunol 1994 : The induction of IL-3 and GM-CSF is partially mediated by IL-1 and IL-6 , which are also produced by bone marrow mononuclear cells
Dührsen et al., Blood 1994 (Leukemia, Experimental) : They were not viable in unstimulated cultures, but formed IgM+ lymphoid colonies in response to interleukin-2 (IL-2), IL-4, IL-5, IL-6 , IL-7, and Steel factor, and macrophage colonies in response to IL-3
Imai et al., Int J Hematol 1994 : IL-6 or IL-11 significantly increased the size and DNA content of megakaryocytes in the presence of IL-3 , while SCF did not affect, or rather decreased, the DNA content
Kita et al., C R Seances Soc Biol Fil 1993 (Disease Models, Animal...) : After HSV-1 infection, IFN-alpha, IFN-beta, IFN-gamma, IL-1 beta, IL-4, IL-6 and TNF-alpha mRNA were significantly induced, but IL-2, IL-3 and IL-5 mRNA were not induced
Cadman et al., Neurosci Lett 1994 (Astrocytoma) : cAMP is not involved in interleukin-1 induced interleukin-6 release from human astrocytoma cells
Tsuji et al., Growth Factors 1994 : IL-6 , induced by IL-3 , stimulates stem cells into cycle and induces stem cells to respond to IL-3
Kellar et al., Exp Hematol 1995 (Leukemia, Myeloid) : IL-3 induced IL-6 secretion in these cells, which was augmented by a protein kinase-C ( PKC ) inhibitor, H7, and reduced by a tyrosine kinase inhibitor, genistein
Kita et al., C R Seances Soc Biol Fil 1994 : Although the expressions of IL-1 beta, IL-4, IL-5, IL-6 , TNF-alpha and IFN-gamma mRNA were detected in all the embryos tested, the expressions of IL-2, IL-3 , IFN-alpha and IFN-beta mRNA were not detected at all
Walsh et al., J Investig Med 1995 (Fanconi Anemia) : For FA ( C ) hematopoietic cell infection, vector supernatant transduction in the presence of recombinant human IL-3 , IL-6 , and SCF was found to be superior to transduction supported by autologous FA ( C ) patient stroma
Carlson et al., J Neurochem 1995 (Astrocytoma) : Prolonged exposure to phorbol ester eliminated subsequent stimulation by phorbol ester but only partially decreased interleukin-1 induced interleukin-6 and had no effect on the activities of selected inhibitors including calphostin C ... We conclude that tyrosine kinase activity is essential for interleukin-1 induced interleukin-6 production in U373 astrocytoma cells and that activity of a phorbol ester-insensitive, atypical protein kinase C isozyme may also be involved
Zitnik et al., Am J Physiol 1993 : cAMP inhibition of interleukin-1 induced interleukin-6 production by human lung fibroblasts
Alderson et al., J Exp Med 1993 : CD40 ligand transfected cells provided a potent costimulus for monocyte TNF-alpha and IL-6 production in the presence of GM-CSF, IL-3 , or IFN-gamma, and enhanced IL-8 production stimulated by GM-CSF or IL-3
Adams et al., Neurosurgery 1994 (Neuroma, Acoustic) : Tumor necrosis factor-alpha, interleukin-1-beta , and cholera toxin all stimulated IL-6 secretion
Hoffmann et al., J Hepatol 1994 : Furthermore, lipopolysaccharide, tumor necrosis factor-alpha, interferon-gamma, interleukin-1 beta and phorbol ester induced interleukin-6 production and, at the same time, suppressed the level of interleukin-6 receptor mRNA
Kita et al., C R Seances Soc Biol Fil 1994 (Stomach Neoplasms) : Although IL-1 beta, IL-4, IL-5, IL-6 , IL-7, IL-8, TNF-alpha, IFN-alpha and IFN-gamma mRNA were detected in all the samples tested, IL-3 and IFN-beta mRNA was not detected at all
Judd et al., Am J Physiol 1995 : ZG cells released IL-6 and TNF, and this release was stimulated by lipopolysaccharide, interleukin-1 alpha, interleukin-1 beta, a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Schneider et al., Exp Hematol 1995 : The effect of IgE on IL-6 production is not mediated by IL-3 since it is not modified by anti-IL-3 antibodies
Ng et al., J Biol Chem 1994 : Differential induction of the interleukin-6 gene by tumor necrosis factor and interleukin-1
Moutabarrik et al., Scand J Immunol 1994 : IL-6 was detected in the culture supernatants of human GEC and its production was enhanced in time and dose dependent manner by lipopolysaccharide (LPS), interleukin-1 beta (IL-1 beta) and tumour necrosis alpha ( TNF-alpha )
Ueo et al., J Am Coll Surg 1994 : The IL-6 secretion by skin explants was significantly enhanced either by tumor necrosis factor or interleukin-1 , while it was inhibited by corticosteroids
Utsunomiya et al., Eur J Pharmacol 1994 (Pleurisy) : However, production of tumor necrosis factor (TNF) and interleukin-1 in the pleural exudate was significantly enhanced by the pretreatment with indomethacin, whereas the interleukin-6 level was reduced
Levine et al., Psychoneuroendocrinology 1994 : Pituitary-adrenal and interleukin-6 responses to recombinant interleukin-1 in neonatal rats
Boxman et al., J Invest Dermatol 1993 : The remaining interleukin-1 activity, however, was sufficient for maximal induction of interleukin-6 production in fibroblasts
Thomassen et al., J Immunother Emphasis Tumor Immunol 1993 : In vitro studies of IL-3 treated normal alveolar macrophage and monocyte population demonstrated that IL-3 significantly augmented TNF and IL-6 secretion in monocytes, but not in alveolar macrophages
Bataille et al., La Revue du praticien 1993 (Multiple Myeloma) : GM-CSF, IL-3 and G-CSF stimulate the IL-6 responsiveness of myeloma cells without affecting the endogenous IL-6 production
Kobayashi et al., Br J Haematol 1993 (Leukemia, Plasma Cell) : Up-regulation of IL-6-receptors by IL-3 on a plasma cell leukaemia cell line which proliferates dependently on both IL-3 and IL-6
Takamatsu et al., J Immunol 1996 : GM-CSF and IL-3 also caused a marked accumulation of both histidine decarboxylase and IL-6 mRNAs in the cells
de Fijter et al., Am J Kidney Dis 1996 : In addition, interleukin-1-beta induced interleukin-6 production by human mesothelial cells was measured in the presence of concentrations of calcium increasing from 0 to 3.0 mmol/L. Fc receptor- mediated uptake of S epidermidis by PMO in the complete absence of Ca++ was comparable to that by PMO incubated in GHBSS with calcium
Aoki et al., Eur J Immunol 1996 : These findings suggest that IL-3 induces the rapid release of IL-4 and IL-6 by non-B/non-T cells, thereby creating an immune milieu conducive to the development of antigen-specific IL-4 and IL-6 secreting Th2 cells
Suzumura et al., Brain Res 1996 : Neither IL-3 nor macrophage-CSF (M-CSF) induced IL-6 production in microglia
Topley et al., J Am Soc Nephrol 1996 : Similarly, interleukin (IL)-1 beta induced IL-6 synthesis by HPMC was also only significantly reduced by the pH 5.2 lactate solution
Bodine et al., Endocrinology 1996 : Finally, interleukin-1 beta and tumor necrosis factor-alpha ( 1-1000 pM ) stimulated dose dependent increases in the secretion of interleukin-6 and monocyte chemoattractant protein-1 at 34 C and 40C
Van Hoffen et al., Am J Pathol 1996 : Using immunohistochemistry, IL-2, IL-3 , and IL-10 protein was detected in biopsies with high rejection grades, whereas few cells expressed IL-6 , IL-8, and IFN-gamma
Meyer et al., Clin Sci (Lond) 1997 (Endotoxemia...) : 3. Administration of endotoxin induced a greater than fourfold increase in brain interleukin-1 , a greater than threefold increase in interleukin-6 and an increase in mRNA for both cytokines
Sugimoto et al., Leukemia 1997 : We found that IL-3 induced a production of IL-6 , G- and GM-CSF from bone marrow cells ... Furthermore, stimulation of bone marrow cells with IL-6 , G- or GM-CSF did not induce the production of IL-3 , indicating a hierarchical regulation of the cytokine production
Jones et al., J Pathol 1997 (Meningioma) : Effect of interleukin-1 and dexamethasone on interleukin-6 production and growth in human meningiomas
Rougier et al., Cytokine 1998 : IL-1 alpha, IL-1 beta, and IL-3 , tumour necrosis factor alpha (TNF-alpha), Stem cell factor (SCF) and granulocyte-macrophage colony stimulating factor ( GM-CSF ) ( at 10 ng/ml ) stimulated IL-6 and IL-8 production in 0 % and 10 % FCS
Porro et al., J Pharmacol Exp Ther 1998 (Shock, Septic) : In vitro experiments showed that ITF1779 inhibited not only huTNFalpha induced cytotoxicity on LM cells but also another response of the same cells, interleukin-1 induced interleukin-6 production
Kozawa et al., Prostaglandins Leukot Essent Fatty Acids 1998 : However, retinoic acid had little effect on the IL-6 synthesis induced by interleukin-1
Staels et al., Nature 1998 (Coronary Disease...) : In these smooth-muscle cells, we find that PPARalpha ligands, and not PPARgamma ligands, inhibit interleukin-1 induced production of interleukin-6 and prostaglandin and expression of cyclooxygenase-2
Ben Amor et al., Exp Hematol 1998 : In the present study we investigated the effect of anti-CD3 stimulation on IL-3 induced histamine, IL-6 , and IL-4 synthesis by murine hematopoietic precursor cells ... Together, our data support the notion that the decrease in IL-3 induced histamine and IL-6 production by splenocytes pretreated with anti-CD3 is mediated, at least in part, by Fas/FasL interactions, suggesting that the activity of extramedullary myeloid precursor cells can be modulated by molecules involved in apoptosis
Tisdale et al., Blood 1998 : Stem cell factor (SCF)/granulocyte colony stimulating factor ( G-CSF ) -mobilized and CD34 enriched PB cells were divided into two equal aliquots and transduced with one of two retroviral vectors carrying the neomycin-resistance gene ( neo ) for 4 days in the presence of interleukin-3 (IL-3), IL-6 , and SCF in the first 5 animals, IL-3/IL-6/SCF/Flt-3 ligand (FLT) in 2 subsequent animals, or IL-3/IL-6/SCF/FLT plus an autologous stromal monolayer ( STR ) in the final 2