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C5 — IL6

Text-mined interactions from Literome

Viedt et al., FASEB J 2000 : The terminal complement complex C5b-9 stimulates interleukin-6 production in human smooth muscle cells through activation of transcription factors NF-kappa B and AP-1 ... We therefore investigated whether the terminal complement complex C5b-9 affects IL-6 production from vascular smooth-muscle cells ( VSMC ) and set out to determine the underlying signal transduction pathway ... Stimulation of human VSMC with C5b-9 resulted in an increase of IL-6 transcript and production of IL-6 protein ... C5b-9 activated the redox-sensitive transcription factors NF-kB and activator protein-1 (AP-1), which were both involved in the induction of IL-6 by C5b-9 , as demonstrated by cis element double stranded ( decoy ) oligonucleotides ( ODN )
Hänsch et al., Int Arch Allergy Appl Immunol 1987 : Furthermore, monocytes release interleukin-1 in response to C5b-9