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IL2 — SOCS1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SOCS1 → IL2 (increases) Cornish et al., J Biol Chem 2003*
  Evidence: SOCS-1 expression is induced by interleukin (IL) 2, IL-4, IL-7, and IL-15,
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS1 (modification, activates)
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS1 (modification, activates)
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS1 (modification, activates)
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS1 (modification, activates)
• NCI Pathway Database IL2-mediated signaling events: IL2R gamma/JAK3/SOCS1 complex (IL2RG-JAK3-SOCS1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, inhibits)
  Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2R gamma/JAK3/SOCS1 complex (IL2RG-JAK3-SOCS1) → IL2 (IL2) (modification, inhibits) Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS1 complex (IL2RB-JAK1-LCK-SOCS1) → IL2 (IL2) (modification, inhibits) Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS1 complex (IL2RB-JAK1-LCK-SOCS1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, inhibits)
  Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species

Text-mined interactions from Literome

Sporri et al., Blood 2001 : The role of JAB/SOCS1/SSI-1 in IL-2 signaling has been analyzed ... JAB/SOCS1/SSI-1 is strongly induced by IL-2 in peripheral blood T cells, and JAB/SOCS1/SSI-1 overexpression strongly inhibits IL-2 induced signal transducer and activator of transcription-5 ( Stat5 ) phosphorylation and transcriptional activity
Cornish et al., J Biol Chem 2003 : SOCS-1 expression is induced by interleukin (IL) 2 , IL-4, IL-7, and IL-15, and SOCS-1-deficient T cells show increased proliferation and prolonged survival in response to IL-2 and IL-4
Yu et al., Invest Ophthalmol Vis Sci 2011 (Autoimmune Diseases...) : Induction of cytokine induced SH2 protein was comparable between patients and volunteers, whereas 80 % of lymphocytes from patients with scleritis failed to induce SOCS1 in response to IL-2