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IL2 — MAP3K8

Text-mined interactions from Literome

Christoforidou et al., Molecular cancer 2004 (Leukemia, T-Cell...) : Animal and tissue culture studies have shown that Tpl2/Cot is involved in interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) production by T-cells contributing to T-cell proliferation
Ballester et al., J Immunol 1997 : Cot kinase regulation of IL-2 production in Jurkat T cells
Tsatsanis et al., Proc Natl Acad Sci U S A 1998 : Herein we show that wild-type and carboxyl-terminally truncated ( activated ) Tpl-2 activate the nuclear factor of activated T cells ( NFAT ) and induce interleukin 2 (IL-2) expression in EL4 cells ... The Tpl-2 mediated induction of IL-2 was not observed in T cell lymphoma lines other than EL4 and Jurkat, as well as in normal T cells
Tsatsanis et al., Oncogene 1998 (Lymphoma, T-Cell) : Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB ... The Tpl-2 kinase activates the nuclear factor of activated T cells ( NFAT ) and induces IL-2 expression in T-cell lines ... Here we show that the activation of the IL-2 promoter by Tpl-2 is inhibited by mutant signaling molecules that inhibit the mitogen activated protein kinase ( MAPK ) or the calcineurin/NFAT pathways and is promoted by combinations of signaling molecules that activate these pathways ... We, therefore, conclude that signals generated by the convergence of the MAPK and the calcineurin/NFAT pathway are necessary and sufficient for the activation of the IL-2 promoter by Tpl-2 ... While the activation of the IL-2 promoter and an NFAT-driven minimal promoter by Tpl-2 was fully blocked by the dominant negative mutant NFAT delta418, it was only partially blocked by the calcineurin inhibitor cyclosporin A suggesting that the Tpl-2 mediated NFAT activation is under the control of a combination of calcineurin dependent and independent pathways