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ADCY5 — IL2

Text-mined interactions from Literome

Katz et al., J Cell Physiol 1992 : Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by down regulating parathyroid hormone receptors
Rodriguez et al., J Biol Chem 2013 : Taken together, these findings suggest that Fsk activation of adenylate cyclase and PKA can negatively regulate IL-2 signaling at multiple levels that include IL-2R complex formation and Jak3/Stat5 activation
Averill et al., Cell Immunol 1988 : Activation of adenylate cyclase , inhibition of cAMP dependent phosphodiesterase, or the direct addition of the cell-permeable cAMP analog, 8-N3-cAMP, increased occupancy of intracellular cAMP receptors, inhibited IL-2 production, and reduced T-cell proliferation
Beckner et al., J Biol Chem 1986 : While PGE2 stimulated adenylate cyclase activity in membrane preparations, neither IL 2 nor TPA inhibited either basal or stimulated membrane adenylate cyclase activity
Evans et al., Nature 1987 : Since it has been observed that IL-2 inhibits the catalytic activity of adenylate cyclase and that agents such as PGE2 which stimulate adenylate cyclase activity inhibit the lymphoproliferative response to IL-2, association of GTP binding proteins with IL-2 signal transduction was investigated
Condie et al., J Biol Chem 1996 : Cannabinoid inhibition of adenylate cyclase mediated signal transduction and interleukin 2 (IL-2) expression in the murine T-cell line, EL4.IL-2