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AKT2 — FOS
Pathways - manually collected, often from reviews:
-
WikiPathways Insulin Signaling:
GSK3B/AKT2/AKT1/SGK3/SGK1/GSK3A/PDPK1/SGK2
→
SRF/ELK1/FOXO1/FOS/JUN/FOXO3/EGR1
(activation)
Text-mined interactions from Literome
Bozinovski et al., J Biol Chem 2002
(MAP Kinase Signaling System) :
Granulocyte/macrophage-colony stimulating factor ( GM-CSF ) regulates lung innate immunity to lipopolysaccharide through
Akt/Erk activation of NFkappa B and
AP-1 in vivo
Mendoza-Gamboa et al., Oncol Rep 2004
(Breast Neoplasms) :
Inhibition of
HER2/Grb2/Akt decreased AP-1 binding activity in HER2 transfected cells, but
increased AP-1 activity in cells that are naturally HER2 overexpressing
Chandrasekar et al., J Biol Chem 2005
:
Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002,
Akt inhibitor, the c-Jun N-terminal kinase (JNK) inhibitor SP600125, antisense JNK and dominant negative MyD88, interleukin-1 receptor associated kinase ( IRAK)-1, IRAK4, and phosphatidylinositol 3-kinase expression all
attenuated IL-18 mediated
AP-1 binding and reporter activity, CXCL16 promoter-reporter activity, and CXCL16 expression
Wang et al., Cancer Res 2005
(MAP Kinase Signaling System) :
Because PTEN is a well-known phosphatase involved in the regulation of phosphatidylinositol 3-kinase (PI-3K)/Akt signaling pathway, taken together with the evidence that
PI-3K/Akt plays an important role in the activation of
AP-1 and NF-kappaB during tumor development, we anticipate that inhibition of AP-1 and NF-kappaB by tumor suppressor p53 seems to be mediated via PTEN, which may be a novel mechanism involved in anticancer activity of p53 protein
Liao et al., Neurochem Int 2007
:
The inductive action of manganese was accompanied by generation of oxidative stress,
activation of mitogen activated protein kinases ( MAPKs ),
AKT , and protein kinase C-alpha (PKC-alpha), and increased NF-kappaB and
AP-1 DNA binding activities
Kim et al., Biol Pharm Bull 2007
(Atherosclerosis) :
Pre-treatment of VSMCs with NQ304 ( 1-10 microM ) was found to significantly inhibit the 5 % FBS induced phosphorylations of ERK1/2 and
Akt , the
activation of
AP-1 and the expression of c-fos
Song et al., Gut 2007
(Adenocarcinoma...) :
Unconjugated bile acids
induce CREB and
AP-1 dependent COX-2 expression in Barrett 's oesophagus and OA through ROS mediated activation of
PI3K/AKT and ERK1/2
Kim et al., Carcinogenesis 2008
(Breast Neoplasms) :
15d-PGJ ( 2 ) -induced COX-2 expression was
mediated by activation of
Akt and subsequently
activator protein-1 (AP-1)
Lin et al., Rheumatol Int 2008
(Chondrosarcoma...) :
Using chondrosarcoma cells stimulated with IL-1beta, the effects of GLN on the mRNA and protein levels of MMP-3, the
activation of JNK, ERK, p38, NF-kappaB, and
AP-1 , the nuclear translocation of NF-kappaB/Rel family members, and
PI3-kinase/Akt activation were studied
Park et al., Biochem Pharmacol 2008
(Bone Resorption) :
In conclusion, bavachalcone inhibits osteoclastogenesis by interfering with the ERK and
Akt signaling pathways and the
induction of
c-Fos and NFATc1 during differentiation
Han et al., Toxicol Appl Pharmacol 2008
:
Phosphatidylinositol 3 (PI3)-kinase, its downstream signaling molecule,
Akt , and mitogen activated protein kinases ( MAPK ) were also significantly
activated by the o, p'-DDT induced
AP-1 and CRE activation
Hou et al., J Cell Biochem 2009
:
US-increased the binding of
c-Fos and c-Jun to the AP-1 element on the BMP-2 promoter and the enhancement of AP-1 luciferase activity was
inhibited by Ly294002 and
Akt inhibitor ... US-increased the binding of c-Fos and c-Jun to the AP-1 element on the BMP-2 promoter and the enhancement of
AP-1 luciferase activity was
inhibited by Ly294002 and
Akt inhibitor
Wu et al., J Am Soc Nephrol 2009
(Diabetes Mellitus, Experimental...) :
PKC is known to mediate glucose induced TGF-beta1 upregulation through the transcription factor AP-1 ; here, inhibitors of phosphoinositide-3-OH kinase, PKC-beta and Akt, and dominant negative
Akt all
prevented glucose induced activation of
AP-1 and upregulation of TGF-beta1
Park et al., Carcinogenesis 2009
(Breast Neoplasms...) :
KPS-A decreased PMA induced transcriptional activation of NF-kappaB and
AP-1 and
inhibited PMA induced phosphorylation of ERK1/2 and
Akt
Shrotriya et al., Cancer Res 2010
(Skin Neoplasms) :
Diallyl trisulfide
inhibits phorbol ester induced tumor promotion, activation of
AP-1 , and expression of COX-2 in mouse skin by blocking JNK and
Akt signaling ... Pharmacologic inhibition of JNK or
Akt by SP600125 or LY294002, respectively,
resulted in diminished AP-1 DNA binding, reduced levels of c-Jun and
c-Fos , and inhibition of COX-2 expression in TPA treated mouse skin ... Taken together, the inhibitory effects of DATS on TPA induced
AP-1 activation and COX-2 expression through modulation of JNK or
Akt signaling may partly account for its antitumor promoting effect on mouse skin carcinogenesis
Vlahos et al., Am J Respir Crit Care Med 2010
(Pneumonia) :
We have previously shown that granulocyte/macrophage colony stimulating factor ( GM-CSF ) regulates lung innate immunity to LPS through
Akt/Erk activation of nuclear factor-kappaB and
activator protein (AP)-1
Chung et al., Dig Dis Sci 2012
(Colorectal Neoplasms...) :
Knockdown of RON inhibits
AP-1 activity and
induces apoptosis and cell cycle arrest through the modulation of
Akt/FoxO signaling in human colorectal cancer cells ... These results indicate that knockdown of RON inhibits
AP-1 activity and
induces apoptosis and cell cycle arrest through the modulation of
Akt/FoxO signaling in human colorectal cancer cells
Chen et al., PloS one 2012
:
HGF mediated
AP-1-luciferase activity and c-Jun binding to the AP-1 element was
reduced by c-Met inhibitor, Ly294002,
Akt inhibitor, and PP2