◀ Back to FANCC

FANCC — FANCD2

Pathways - manually collected, often from reviews:

• BioCarta brca1 dependent ub ligase activity: FA complex complex (FANCA-FANCC-FANCE-FANCF-FANCG) → FANCD2/ubiquitin complex (FANCD2) (modification, collaborate)
  
• BioCarta brca1 dependent ub ligase activity: FANCD2/ubiquitin complex (FANCD2) → FA complex/FANCD2/ubiquitin complex (FANCA-FANCC-FANCE-FANCF-FANCG) (modification, collaborate)
  
• BioCarta role of brca1 brca2 and atr in cancer susceptibility: FA complex complex (FANCA-FANCC-FANCE-FANCF-FANCG) → FANCD2/ubiquitin complex (FANCD2) (protein ubiquitination, activates)
  
• BioCarta role of brca1 brca2 and atr in cancer susceptibility: FA complex complex (FANCA-FANCC-FANCE-FANCF-FANCG) → FANCD2 (protein ubiquitination, activates)
• NCI Pathway Database Fanconi anemia pathway: FA core complex complex (FANCA-FANCB-FANCC-FANCE-FANCF-FANCG-C17orf70-HES1-FANCL-UBE2T) → FANCD2/FANCI complex (FANCD2-FANCI) (modification, activates)
  Timmers et al., Mol Cell 2001, Pace et al., EMBO J 2002, Meetei et al., Nat Genet 2003, Montes de Oca et al., Blood 2005, Meetei et al., Nat Genet 2004, Meetei et al., Nat Genet 2005, Gurtan et al., J Biol Chem 2006, Machida et al., Mol Cell 2006, Ciccia et al., Mol Cell 2007, Ling et al., EMBO J 2007, Smogorzewska et al., Cell 2007, Sims et al., Nature structural & molecular biology 2007, Kim et al., Blood 2008, Ishiai et al., Nature structural & molecular biology 2008, Collins et al., Blood 2009, Alpi et al., Mol Cell 2008, Longerich et al., J Biol Chem 2009
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BARD1 signaling events: FA complex/FANCD2/Ubiquitin complex (FANCA-FANCC-FANCE-FANCF-FANCG-FANCL-FANCD2) → FANCD2 (FANCD2) (modification, collaborate)
• NCI Pathway Database BARD1 signaling events: FA complex/FANCD2/Ubiquitin complex (FANCA-FANCC-FANCE-FANCF-FANCG-FANCL-FANCD2) → FA complex complex (FANCA-FANCC-FANCE-FANCF-FANCG-FANCL) (modification, collaborate)
  
• NCI Pathway Database BARD1 signaling events: FANCD2 (FANCD2) → FA complex complex (FANCA-FANCC-FANCE-FANCF-FANCG-FANCL) (modification, collaborate)
  
• Reactome Reaction: FANCC → FANCD2 (reaction) Garcia-Higuera et al., Mol Cell 2001, Machida et al., Mol Cell 2006

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: FANCD2 — FANCC (physical association, affinity chromatography technology) Gordon et al., J Biol Chem 2005*
• IRef Hprd Interaction: FANCD2 — FANCC (in vivo) Wilson et al., Carcinogenesis 2001*
• IRef Intact Interaction: Complex of FANCA-FANCF-FANCG-FANCD2-FANCE-FANCC (association, coimmunoprecipitation) Pace et al., EMBO J 2002
• IRef Ophid Interaction: FANCD2 — FANCC (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: FANCD2 — FANCC (aggregation, confirmational text mining) Wilson et al., Carcinogenesis 2001*

Text-mined interactions from Literome

Freie et al., J Biol Chem 2004 (Fanconi Anemia) : Finally, fibroblasts lacking FANCD2 were found to have a G2 checkpoint phenotype similar to FANCC-deficient cells, indicating that FANCD2 , which is activated by the FA complex , was also required to maintain the G2 checkpoint
Shen et al., Mol Cell 2009 (Breast Neoplasms) : FANCD2 , but not FANCJ and FANCN, requires the FA core complex for its recruitment