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EPHB2 — STAT3

Text-mined interactions from Literome

Lim et al., J Biol Chem 1999 : Inhibitors of ERK and p38 did not inhibit UV-induced Stat3 serine phosphorylation, suggesting that neither of them is involved
Tancredi et al., J Neurochem 2000 (Synaptic Transmission) : The IL-6 induced inhibition of PTP and LTP was accompanied by a simulation of STAT3 tyrosine phosphorylation and an inhibition of MAPK/ERK dual phosphorylation, in the absence of changes in the state of activation of SAPK/JNK
Song et al., Chin Med J (Engl) 2001 (Multiple Myeloma) : To investigate the regulation effect of protein kinase ERK on the activation of transcription factor STAT3 in response to IL-6 in the Sko-007 human myeloma cell line ... ERK-AS inhibited STAT3 activation by IL-6
Frost et al., Mol Cancer Ther 2002 : In signaling studies, addition of stem cell factor (SCF) induced phosphorylation of ERK and Akt by WTKit, and ERK, Akt and STAT3 by V560GKit, which were all blocked by Imatinib
Booz et al., Basic Res Cardiol 2003 : These results are consistent with Erk mediated STAT3 Ser727 phosphorylation leading to STAT3 Tyr705 dephosphorylation, and accounting for angiotensin II-mediated STAT3 inhibition in cardiomyocytes
Kanai et al., Oncogene 2003 (Stomach Neoplasms) : Western blot analysis and electrophoretic mobility shift assay showed that DIF-1 inhibited STAT3 activity in an MEK-ERK dependent manner in gastric cancer cell lines, AGS and MKN28
Nagata et al., Arterioscler Thromb Vasc Biol 2003 : A MEK1 inhibitor, PD98059, not only blocked ERK1/2 phosphorylation but also abolished the OSM induced MMP-9 upregulation, whereas the MMP-9 induction was not affected by overexpressing dominant negative STAT3
Tian et al., Cell Res 2004 : The present study is aiming to explore the regulatory effect of activation of ERK1/2 evoked by HSS on STAT3 phosphorylation and STAT3 signaling
Jo et al., Life Sci 2004 (Translocation, Genetic) : We also found that WKYMVm stimulated extracellular signal regulated kinase ( ERK ), and that ERK activity is required for STAT3 serine phosphorylation
Li et al., Chin Med J (Engl) 2004 (Cardiomegaly) : However, it has recently been found that STAT3 may be negatively regulated by ERK1/2 in gp130 dependent signaling ... In this study, we examined whether STAT3 activity was negatively regulated by ERK1/2 during CT-1 induced signaling in rat cardiomyocytes and, if so, whether such crosstalk interfered with the hypertrophic effect of CT-1 and, furthermore, whether the mechanism underlying the crosstalk involved phosphorylation of serine 727 ( S727 ) in STAT3 ... Inhibition of ERK1/2 by U0126 resulted in an increase of CT-1 induced tyrosine phosphorylation of STAT3 and, consequently, the protein-to-DNA ratio and [ ( 3 ) H ] -leucine incorporation ... The inhibition of ERK1/2 increases the activity of STAT3 , which, in turn, enhances the hypertrophic effect of CT-1
Venkatasubbarao et al., Cancer Res 2005 (Adenocarcinoma...) : The biological significance of ERK mediated inhibition of STAT3 ( ( Tyr705 ) ) phosphorylation was further assessed by treating the cells with an inhibitor ( PD98059 ) of mitogen activated protein kinase kinase ( MEK ) or by transfecting the cells with a vector that expresses constitutively active MEK-1 ... Expression of constitutively active MEK-1 caused an increase of ERK activity and inhibited STAT3 ( ( Tyr705 ) ) phosphorylation
Kakisis et al., Int J Biochem Cell Biol 2005 : Serine phosphorylation of STAT-3 was increased by 2-fold after 15 min of cyclic strain, while tyrosine phosphorylation was increased by 2.3-fold after 60 min. Inhibition of ERK1/2 by PD98059 prevented serine phosphorylation of STAT-3 , whereas inhibition of Src by PP1 prevented STAT-3 tyrosine phosphorylation ... Serine phosphorylation of STAT-3 is mediated by ERK1/2 , while tyrosine phosphorylation is mediated by Src
Nowroozi et al., Hum Mol Genet 2005 (Thanatophoric Dysplasia) : Using PC12 cell lines stably expressing inducible mutant receptors containing the TDII mutation, K650E, sustained activation of ERK1/2 and activation of STAT1 and STAT3 , but not STAT5, is observed in the absence of ligand
Pai et al., Biochem Biophys Res Commun 2005 (Stomach Neoplasms) : Leptin induced STAT3 phosphorylation is independent of ERK2 activation
Miranda et al., Leuk Res 2005 (MAP Kinase Signaling System) : Inhibition of MEK/ERK signaling also significantly reduced cytokine induced DNA binding activities of STAT 3 and PU.1, transcription factors that have been implicated in myeloid differentiation
Arany et al., Kidney Int 2006 : STAT3 attenuates EGFR mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells ... Inhibition of JAK2 or STAT3 lead to increased ERK activation and survival of TKPTS cells during severe oxidative stress ... Our data suggest a role of tyrosine phosphorylated STAT3 in the suppression of ERK activation
Washburn et al., Neuroscience 2006 : P2 receptors can couple to extracellular signal regulated protein kinases ( ERK ) and we found that inhibition of ERK signaling blocked phosphorylation of Ser727-STAT3
Frias et al., Cardiovasc Res 2007 (Cardiomegaly) : The activation of Stat3 occurs mainly through EP4 and involves ERK1/2 as well as newly synthesized protein ( s )
Plaza-Menacho et al., J Biol Chem 2007 (Carcinoma, Medullary...) : Ras/ERK1/2 mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation
Giani et al., Exp Physiol 2008 : Angiotensin- ( 1-7 ) has a dual role on growth promoting signalling pathways in rat heart in vivo by stimulating STAT3 and STAT5a/b phosphorylation and inhibiting angiotensin II-stimulated ERK1/2 and Rho kinase activity
Souza et al., Toxicol Lett 2009 : NADPH oxidase and ERK1/2 are involved in cadmium induced-STAT3 activation in HepG2 cells
Sambade et al., Radiother Oncol 2009 (Breast Neoplasms...) : In SUM102 cells, an EGFR+ basal breast cancer cell line, exposure to ionizing radiation elicited strong activation of ERK1/2 and JNK, which was blocked by lapatinib, and weak/no activation of p38, AKT or STAT3
Lee et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2009 : In cultured Schwann cells, we noted that ERK activation is required for the serine phosphorylation of STAT3 by neuropoietic cytokine interleukin-6 (IL-6) ... Serine phosphorylated STAT3 by IL-6 was transported into Schwann cell nuclei, thereby indicating that ERK may regulate the transcriptional activity of STAT3 via the induction of serine phosphorylation of STAT3 ... Finally, we determined that the inhibition of ERK prevented injury induced serine phosphorylation of STAT3 in an ex-vivo explants culture of the sciatic nerves
Kim et al., Oncol Rep 2010 (Leukemia, Myeloid, Acute) : The blocking of STAT3 phosphorylation with the specific inhibitor, AG490, significantly reduced leptin induced ERK1/2 phosphorylation and cellular proliferation, whereas the blocking of ERK1/2 activation by the specific ERK1/2 inhibitor, PD98059, did not affect the STAT3 phosphorylation or leptin induced proliferation in HEL cells
Sakai et al., J Dent Res 2010 : VEGF induced ERK and AKT phosphorylation ( indicative of differentiation ), while inhibiting phosphorylation of STAT3 ( indicative of ` stemness ' )
Litherland et al., J Biol Chem 2010 : STAT3 gene silencing or ERK pathway inhibition also resulted in loss of IL-1 + OSM stimulated c-fos and collagenase expression
Shan et al., J Immunol 2010 (Respiratory Hypersensitivity) : Furthermore, using biochemical and genetic approaches, we found that TSLP induced proinflammatory gene expression in HASM involved the transcriptional mechanisms, MAPKs ( ERK1/2 , p38, and JNK ), and STAT3 activation
Li et al., Int J Mol Med 2011 (Carcinoma...) : ERK1/2 and p38 proteins regulate STAT3 expression in SKOV3 cells, while STAT3 may be pivotal to the proliferation of SKOV3 cells in vitro
Yao et al., J Cell Biochem 2011 : Inhibition of STAT3 tyrosine phosphorylation was found to be achieved through suppression of Src, JAK1, and JAK2, while suppression of STAT3 serine phosphorylation was mediated by inhibition of ERK activation
Liu et al., J Huazhong Univ Sci Technolog Med Sci 2011 (Adenocarcinoma...) : The results showed that leptin induced the phosphorylation of STAT3 and the activation of ERK1/2 in a time- and dose dependent manner in the Ishikawa endometrial cancer cells
Li et al., PloS one 2011 : Exogenous CNTF, CT1, or OsM induces STAT3 phosphorylation, and OsM also induces the phosphorylation of ERK1/2 ( p44/42 MAP kinase )
Luo et al., Life Sci 2012 : High glucose enhances TGF-ß1 expression in rat bone marrow stem cells via ERK1/2 mediated inhibition of STAT3 signaling
Luckett-Chastain et al., J Interferon Cytokine Res 2012 : Inhibition of STAT3 in fibroblasts potentiated IL-6R induced ERK phosphorylation and vice versa
Chen et al., J Mol Med (Berl) 2012 (Multiple Myeloma) : Further analysis demonstrated that ISL not only downregulated IL-6 expression but also significantly decreased levels of phosphorylated ERK and STAT3 and could inhibit phosphorylation levels of ERK and STAT3 induced by recombinant human IL-6, which are critical signaling proteins in IL-6 signaling regulation networks
Bento et al., J Dent Res 2013 (MAP Kinase Signaling System) : Exposure of SHED to EGM2-MV supplemented with VEGF induced potent activation of ERK and Akt signaling, while it inhibited phosphorylation of STAT3 ... Notably, genetic ( MEK1 silencing ) or chemical ( U0126 ) inhibition of ERK signaling restored constitutive STAT3 phosphorylation and inhibited the differentiation of SHED into endothelial cells
Megeney et al., Dev Genet 1996 : In differentiated myotubes, LIF treatment resulted in the tyrosine phosphorylation of both STAT3 and STAT1, but ERK phosphorylation was not detectable, and bFGF treatment did not lead to STAT1 or STAT3 tyrosine phosphorylation
Jain et al., Oncogene 1998 : Here, we report that ERK2 activated by its upstream kinase, MEK1, represses Stat3 transcriptional activity induced by Src or Jak-2