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EPHB2 — NPPA
Text-mined interactions from Literome
Pandey et al., Biochem Biophys Res Commun 2000
:
We have examined the
effect of
atrial natriuretic peptide (ANP) and its guanylyl cyclase/natriuretic peptide receptor-A (NPRA) on mitogen activated protein kinase/extracellular signal regulated kinase 2 (
MAPK/ERK2 ) activity in rat mesangial cells overexpressing NPRA ...
ANP inhibited agonist stimulated activity of
MAPK/ERK2 by 65-75 % in cells overexpressing NPRA, whereas in vector transfected cells, its inhibitory effect was only 18-20 % ... NPRA antagonist A71915 and KT5823, a specific inhibitor of cGMP dependent protein kinase ( PKG ) completely reversed the inhibitory
effect of
ANP on
MAPK/ERK2 activity
Ueyama et al., J Mol Cell Cardiol 2000
(Cardiomegaly...) :
Overexpression of MEK1 EE in MCs activated
ERK1/2 and subsequently
induced atrial natriuretic peptide (ANP) mRNA expression
Kook et al., Am J Physiol Heart Circ Physiol 2003
:
ANP increased the expression of phospho-Akt and of
phospho-ERK1/2 within 1.5 h
Müller et al., Endocrinology 2006
(Leydig Cell Tumor) :
LPA, but not
ANP ,
enhances ERK phosphorylation and induces cell rounding together with a dramatic reorganization of actin filaments
You et al., Endocrinology 2009
:
In contrast,
ANP reduced the levels of
phospho-ERK in INS-1E cells
O'Tierney et al., J Physiol 2010
:
Ang II-stimulated
ERK and Akt phosphorylation was
inhibited by 100 nm
ANP
Isono et al., Kidney Int 1998
:
We have reported that both extracellular signal regulated kinase ( ERK ) and c-Jun NH2-terminal kinase (JNK) are activated by ET-1 and ET-1 induced activation of
ERK is
inhibited by
ANP