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EPHB2 — MITF
Text-mined interactions from Literome
Molina et al., J Biol Chem 2005
:
Furthermore, D-site peptides, which are able to potently inhibit ERK2 mediated phosphorylation of the Elk-1 transcription factor ( IC50= 3 microm ), are relatively poor inhibitors of
ERK2 mediated phosphorylation of
MITF , exhibiting > 15-fold selectivity for inhibition of Elk-1 versus MITF
Choi et al., J Dermatol Sci 2006
(Hypopigmentation) :
These results suggest that hinokitiol induced
ERK phosphorylation
reduces MITF and TYR transcription, and mediates the action of hinokitiol on melanogenesis
Jin et al., Arch Dermatol Res 2008
:
Furthermore, ERK functionally regulated the MbetaCD induced melanin formation in melanocytes ; a
ERK inhibitor, PD98059, almost completely
attenuated the MbetaCD mediated inhibition of melanin synthesis and down-regulation of
MITF and tyrosinase expression
Park et al., International journal of cell biology 2009
:
Then the activated
MAPK/ERK caused an acute phosphorylation of
MITF , followed by proteosome mediated degradation of MITF, the key transcription factor for melanogenic proteins [ Wu et al. ( 2000 ) Gene & Development : 14 ]
Wu et al., J Biomed Sci 2011
(Hyperpigmentation...) :
Cpc exerted dual antimelanogenic mechanisms by upregulation of
MAPK/ERK dependent degradation of
MITF and downregulation of p38 MAPK regulated CREB activation to modulate melanin formation
Nakanishi et al., Int J Mol Med 2013
:
Blocking of the activity of Nox with diphenylene iodonium inhibited ROS production,
activation of extracellular signal regulated kinase (
ERK ), and the expression of RANK, PU.1 and
MITF
Kim et al., Life Sci 2013
:
Furthermore, a specific
ERK pathway inhibitor, PD98059, blocked GGA induced melanin reduction and then
prevented downregulation of
MITF and tyrosinase by GGA