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EPHB2 — IGF1R
Text-mined interactions from Literome
Swantek et al., Endocrinology 1999
:
Prolonged activation of
ERK2 by epidermal growth factor and other growth factors
requires a functional
insulin-like growth factor 1 receptor
Giacco et al., FASEB J 2006
:
Conversely, inhibition of IGF-1 signaling by Ag1024 and expression of a dominant negative
IGF-1R mutant selectively
reduced the stimulation of
ERK1/2 by TAPs and fibroblast released factors, with minor changes of Akt/PKB activity
Allard et al., American journal of physiology. Renal physiology 2007
(Albuminuria...) :
The early phase of diabetes was found to be associated with an increase in glomerular expression of
IGF1-R , PDGF-R, and TGF-beta-RII and
activation of IRS1,
Erk 1/2, and Smad 2/3
Papageorgiou et al., Mol Med 2008
(Prostatic Neoplasms) :
Because the IGF-1R signaling is probably the most important host tissue ( bone ) metastasis microenvironment related survival signaling for prostate cancer cells, we conclude that rosiglitazone effects on
IGF-1R mediated activation of
ERK1/2 and AKT could have clinical implications for the management of androgen ablation-refractory and chemotherapy-resistant advanced prostate cancer with bone metastasis
Zhong et al., J Biol Chem 2009
(Neoplasms) :
Because IGF1R signaling is involved, PI3K/AKT constitutes only one of the prosurvival pathways that are activated by 2-DG treatment ; we validated that
MEK-ERK signaling was also induced in an
IGF1R dependent manner in some cancer cell lines
Pandey et al., J Biol Inorg Chem 2010
:
Cell-type-specific
roles of
IGF-1R and EGFR in mediating Zn2+ induced
ERK1/2 and PKB phosphorylation
Jameson et al., Mol Cancer Ther 2011
(Carcinoma, Squamous Cell...) :
In both the cell lines,
IGF1R induced
Erk , but not Akt, activation was eliminated by gefitinib
Lin et al., EMBO Mol Med 2012
(Adenocarcinoma...) :
Trop-2 could attenuate
IGF-1R signalling
mediated AKT/ß-catenin and
ERK activation through a direct binding of IGF1
Baloucoune et al., PloS one 2012
(MAP Kinase Signaling System) :
Furthermore, we demonstrate that GB1asa
induces ERK1/2 phosphorylation through Gi/o proteins and PLC dependent
IGF-1R transactivation
Appleman et al., Mol Cancer Res 2012
:
KRAS ( G12D ) - and BRAF ( V600E ) -induced transformation of murine pancreatic epithelial cells requires
MEK/ERK stimulated
IGF1R signaling
Estañ et al., Biochem Pharmacol 2012
(Leukemia) :
In summary 2-DG elicits
IGF-1R mediated AMPK inactivation and Akt and
ERK activation, which facilitates or restrain apoptosis, respectively
Fujita et al., J Biol Chem 2013
:
Inhibitors of IGF1R, Src, AKT, and
ERK1/2 did not
suppress avß3-IGF-IGF1R ternary complex formation, suggesting that activation of these kinases are not required for ternary complex formation
Shu et al., Cellular oncology (Dordrecht) 2013
(Carcinoma, Hepatocellular...) :
Klotho is a tumor suppressor that, through the regulation of
IGF-1R phosphorylation and subsequent
activation of downstream Akt-p70S6K and
ERK signaling, regulates HCC tumor cell proliferation, apoptosis, autophagy and invasion