◀ Back to EPHB2
EPHB2 — HSP90AA1
Text-mined interactions from Literome
Dou et al., Acta Biochim Biophys Sin (Shanghai) 2005
:
We showed that
Hsp90 inhibitors
reduce ERK phosphorylation without affecting the total ERK protein level
Koga et al., Proc Natl Acad Sci U S A 2006
:
Hsp90 inhibition transiently activates Src kinase and
promotes Src dependent Akt and
Erk activation
Babchia et al., Invest Ophthalmol Vis Sci 2008
(Melanoma...) :
The inhibition of
HSP90 downregulated B-Raf, decreased cell proliferation, and
reduced activation of
MEK/ERK in uveal melanoma cell lines expressing WT B-Raf
Bisel et al., J Cell Biol 2008
:
ERK regulates Golgi and
centrosome orientation towards the leading edge through GRASP65
Hackl et al., Surgery 2010
(Acute Disease...) :
Inhibition of
HSP90 effectively
diminished the constitutive phosphorylation of Akt,
Erk , and STAT3 in PHHs. Conversely, inhibition of HSP90 significantly increased the expression of both VEGF and HGF mRNA, and induced HSP70 protein in PHH cultures in vitro
Bhat et al., Mol Immunol 2010
:
Our results demonstrate that binding of CpG ODN ( 2007 ) to
Hsp90 induces activation of
ERK2 and AKT phosphorylation leading to the production of high levels of IFN-gamma, IL-6, MIP-3alpha and nitric oxide ( NO )
Colello et al., J Biol Chem 2012
(MAP Kinase Signaling System) :
Integrins
regulate microtubule nucleating activity of
centrosome through mitogen activated protein kinase/extracellular signal regulated kinase kinase/extracellular signal regulated kinase (
MEK/ERK ) signaling