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BCR — EPHB2
Text-mined interactions from Literome
Tuscano et al., Blood 1999
:
Because extracellular signal regulated kinases ( ERKs ) couple upstream signaling pathways to gene activation and are activated by B-cell antigen receptor (BCR) signaling, we examined whether CD22 ligation also activated ERKs and/or modified
BCR induced
ERK activation
Adachi et al., J Immunol 2000
(Calcium Signaling...) :
In this paper we demonstrate that expression of CD72 down-modulates both extracellular signal related kinase ( ERK ) activation and Ca2+ mobilization induced by BCR ligation in the mouse B lymphoma line K46micromlambda, whereas
BCR mediated
ERK activation was not reduced by the ITIM mutated form of CD72 ... Moreover, coligation with CD72 with BCR reduces
BCR mediated
ERK activation in spleen B cells of normal mice
Swart et al., Biochem Biophys Res Commun 2000
:
We demonstrate that JNK and
ERK activities are not
affected by
BCR cross linking, suggesting that these MAPKs are not directly involved in initiating the apoptotic cascade
Richards et al., J Immunol 2001
(MAP Kinase Signaling System) :
PD98059 or U0126 treatment substantially inhibited the
BCR induced activation of the extracellular signal regulated kinase (
ERK ) forms of mitogen activated protein kinase in the immature B cell line WEHI-231, in immature splenic B cells, and in mature splenic B cells
Wu et al., J Immunol 2001
(Severe Combined Immunodeficiency) :
Although both CD72 and
BCR induced Btk dependent
ERK activation, CD72 mediated proliferation is more resistant to blocking of ERK activity than that of BCR, as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP, agents that inhibit ERK activity
Li et al., EMBO J 2001
(MAP Kinase Signaling System) :
In vivo expression of a Grb2 mutant where Tyr209 was changed to phenylalanine enhanced
BCR/ABL induced
ERK activation and fibroblast transformation, and potentiated and prolonged Grb2 mediated activation of Ras, mitogen activated protein kinase and c-Jun N-terminal kinase in response to EGF stimulation
Niiro et al., J Exp Med 2002
(Calcium Signaling) :
Moreover,
BCR induced
activation of extracellular signal regulated kinase (
ERK ), c-jun NH2-terminal kinase ( JNK ), and p38 mitogen activated protein kinase ( MAPK ) pathways was impaired in Bam32 ( -/- ) cells but not the activation of Akt related pathways
Piatelli et al., J Biol Chem 2002
:
We report that inhibition of mitogen activated protein kinase/extracellular signal regulated kinase kinase ( MEK)-1/2 blocked
BCR induced activation of extracellular signal regulated kinase (
ERK )
Jacob et al., J Biol Chem 2002
:
Here we demonstrate through the use of PI 3-kinase inhibitors and a dominant negative PI 3-kinase construct that the
BCR induced phosphorylation and activation of
ERK is dependent on PI 3-kinase
Koncz et al., Immunol Lett 2002
:
We compared the
BCR induced intracellular [ Ca2+ ] transient, protein tyrosine phosphorylation and
ERK phosphorylation, furthermore, the activation of Elk-1 and CREB transcription factors
Kawauchi et al., Int J Hematol 2002
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
In contrast,
BCR cross linking
resulted in
ERK activation, although the activation in quiescent cells was case dependent ... These results suggest that some signaling pathways, such as the
activation of
ERK through
BCR , are functional in B-CLL cells despite the extensive impairment of signaling pathways
Brummer et al., EMBO J 2002
:
Loss of Raf-1 has no effect on
BCR mediated
ERK activation, whereas B-Raf-deficient DT40 cells display a reduced basal ERK activity as well as a shortened BCR mediated ERK activation ... Our study shows that
BCR mediated
ERK activation involves a cooperation of both B-Raf and Raf-1, which are activated specifically in a temporally distinct manner
Wilson et al., Oncogene 2002
(Cell Transformation, Neoplastic...) :
These data implicate the Src kinase family in Stat5 and
Erk activation downstream of
Bcr-Abl , and identify myeloid-specific Src kinases as potential drug targets in CML
Janssen et al., Nat Immunol 2003
:
Decreased LAB expression led to a reduction in
BCR mediated calcium flux and
Erk activation
Christian et al., J Biol Chem 2003
:
Preventing Rap activation had no effect on
BCR induced activation of
ERK
Bell et al., Eur J Immunol 2004
:
BCR stimulated
ERK and IkappaBalpha phosphorylation were PLCgamma2 dependent, while calcium flux was reduced, but not abrogated, in the absence of PLCgamma2, suggesting an ancillary role for PLCgamma1
Herrin et al., J Biol Chem 2005
(Lymphoma, B-Cell) :
With respect to MAPK activation, HSH2 was not observed to alter the activation of
ERK or p38 in
response to
BCR ligation, but it does significantly potentiate JNK activation
Guo et al., J Immunol 2005
:
B cell receptor (BCR) cross-talk : IL-4 creates an alternate pathway for
BCR induced
ERK activation that is phosphatidylinositol 3-kinase independent ... As in the classical pathway,
BCR induced
ERK activation in the new, PI3K independent pathway required MEK and was reflected in c-Raf
Togni et al., Mol Cell Biol 2005
:
Similarly,
B-cell receptor (BCR) mediated total tyrosine phosphorylation and phosphorylation of
Erk , p38, and JNK, as well as immunoreceptor mediated Ca ( 2+ ) responses, are normal in SKAP-HOM ( -/- ) animals
Xu et al., J Immunol 2006
(Calcium Signaling...) :
Intracellular calcium signaling and
ERK activation in
response to
BCR engagement were also proportionately decreased and delayed, respectively, with stepwise reduction of plcgamma2 dosage in a BLNK ( null ) background
de la Fuente et al., Mol Cell Biol 2006
:
B-cell proliferation, cell cycle progression, PLC-gamma2 phosphorylation, calcium mobilization, NF-ATp dephosphorylation, and
Erk and Jnk activation in
response to
B-cell receptor (BCR) ligation were all impaired
Angyal et al., Ann N Y Acad Sci 2006
:
RNA silencing experiments showed that knocking down Gab1 adaptor protein in BL41 human Burkitt lymphoma cells significantly reduced
B cell receptor (BCR) induced
Erk phosphorylation, indicating that Gab1 plays a pivotal role in regulating Erk activity in B cells
Haga et al., Proc Natl Acad Sci U S A 2007
:
Coligation of this fusion protein with the B cell receptor (BCR) inhibited
BCR mediated calcium mobilization, intracellular tyrosine phosphorylation, and
Erk kinase activation
Chew et al., J Biol Chem 2007
:
The overexpression of LPXN in mouse A20 B lymphoma cells led to the suppression of
BCR induced activation of JNK, p38 MAPK, and, to a lesser extent, Akt, but not
ERK and NFkappaB, suggesting that LPXN can selectively repress BCR signaling
McCabe et al., Toxicological sciences : an official journal of the Society of Toxicology 2007
:
Using Western blotting and phospho-specific flow cytometry, we now show that the kinetics and magnitude of
BCR mediated
activation of
ERK-MAPK are markedly attenuated in WEHI-231 cells and splenic B cells that have been exposed to low and nontoxic burdens of Hg ( +2 )
Donahue et al., Eur J Immunol 2007
:
BCR mediated phosphorylation of Akt and
Erk is sensitive to the PI3K catalytic inhibitor wortmannin in both marginal zone ( MZ ) and follicular ( FO ) cells
Sommers et al., Int Immunol 2008
:
It was previously shown that Bam32-deficient mice have defects in various aspects of B cell activation including
B cell receptor (BCR) induced
Erk activation, BCR induced proliferation and T-independent antibody responses
Lee et al., Journal of cell communication and signaling 2007
:
In contrast,
BCR induced activation of
ERK , JNK, p38, and Akt was not affected by ROS depletion ... The differential requirement for ROS in the
activation of
ERK , JNK, p38, and Akt by the
BCR , CD40, and CXCR4 likely reflects the multiplicity of upstream activators for each of these kinases, only some of which may be regulated in a redox dependent manner
Ha et al., J Leukoc Biol 2008
:
We found that in CB B cells
activation of extracellular signal regulated kinase (
ERK ) and p38 following ligation of CD40 but not of the
B-cell antigen receptor (BCR) was inefficient
Gross et al., J Immunol 2009
:
Wild-type mature follicular B cells were less sensitive to BCR stimulation than were immature transitional stage 1 B cells with regard to
BCR induced calcium elevation and
ERK MAPK
activation
Aceves-Luquero et al., PloS one 2009
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
In fact,
Bcr/Abl activates preferentially
Erk2 in transient transfection in a dose dependent fashion through the c-Abl part of the chimeric protein
Sanchez-Aguilera et al., Leukemia 2010
(Disease Models, Animal...) :
Phosphorylation of AKT and
ERK in
response to
BCR stimulation was notably decreased in Emu-TCL1 ( Tg ) ; Rhoh ( -/- ) splenocytes
Rowland et al., J Exp Med 2010
:
Ras activation of
Erk restores impaired tonic
BCR signaling and rescues immature B cell differentiation
Taniguchi et al., PloS one 2013
:
Here, we present data indicating that the increase in intracellular zinc level induced by ZIP9/SLC39A9 ( a ZIP Zrt-/Irt-like protein ) plays an important role in the activation of Akt and
Erk in
response to
BCR activation
Uhde et al., Int Immunol 2013
:
BCR engagement
led to reduced activation of LYN, SYK and
ERK1/2 resulting in reduced numbers of proliferating cells in all CD83tg B cell subsets
Sutherland et al., J Immunol 1996
:
We found that
BCR engagement in WEHI-231 cells
caused a 15- to 20-fold activation of
ERK2 and a 2- to 3-fold stimulation of ERK1 ... CD40 did not activate either of these kinases, nor did it affect
BCR induced
ERK activation ... In summary, the
BCR strongly activates ERK2 and weakly
activates ERK1 , JNK, and p38, while CD40 markedly stimulates the JNK and p38 kinases
Chan et al., Curr Biol 1998
:
Although the initiation of
BCR signaling in lyn-/- B cells is delayed, BCR induced
ERK2 activation and proliferation are
enhanced
Hashimoto et al., J Exp Med 1998
:
Here we demonstrate that the
BCR induced
ERK activation is reduced by loss of Grb2 or expression of a dominant negative form of Ras, RasN17, whereas this response is not affected by loss of Shc
Jiang et al., J Exp Med 1998
:
BCR mediated activation of ERK2, although maintained in Lyn-deficient cells, was abolished in Syk-deficient cells and partially inhibited in Btk-deficient cells, indicating that
BCR mediated ERK2 activation requires Syk and that sustained
ERK2 activation
requires Btk