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CPOX — MMP13

Text-mined interactions from Literome

Pillinger et al., J Immunol 2003 : Our data indicate that : 1 ) ERK activation mediates MMP-1 but not MMP-13 release from FLSCs, 2 ) COX-2 derived E PGs inhibit MMP-1 release from FLSCs via inhibition of ERK, and 3 ) COX inhibitors, by attenuating PGE inhibition of ERK, enhance the release of MMP-1 by FLSC
Noguchi et al., Oral Microbiol Immunol 2005 : Indomethacin, a nonselective cyclooxygenase inhibitor, and NS-398, a specific cyclooxygenase-2 (COX-2) inhibitor, significantly enhanced IL-1alpha induced MMP-13 production in periodontal ligament cells, although both the agents completely inhibited IL-1alpha induced PGE2 production
Spinella et al., Cancer Res 2007 (Melanoma...) : Moreover, COX-1/COX-2 inhibitors block ET-induced PGE ( 2 ) and VEGF secretion, matrix metalloproteinase ( MMP ) activation, and cell invasion, indicating that both enzymes function as downstream mediators of ET-induced invasive properties