◀ Back to CCR5
CCR5 — CXCL12
Pathways - manually collected, often from reviews:
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BioCarta role of ß-arrestins in the activation and targeting of map kinases:
G-protein receptor/G-gamma/G-beta/G-alpha-S/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-GNAS)
→
Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2)
(modification, collaborate)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
G-protein receptor/G-gamma/G-beta/G-alpha-S/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-GNAS)
→
Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
(modification, collaborate)
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BioCarta role of ß-arrestins in the activation and targeting of map kinases:
G-alpha-s/GTP complex (GNAS)
→
Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
(modification, collaborate)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2)
→
Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
(modification, collaborate)
-
BioCarta chrebp regulation by carbohydrates and camp:
Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
→
GPCR/g-alpha-s/g-beta/g-gamma/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNAS-GNGT1-GNB1)
(modification, collaborate)
-
BioCarta chrebp regulation by carbohydrates and camp:
Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
→
GTP/G-alpha-S complex (GNAS)
(modification, collaborate)
-
BioCarta chrebp regulation by carbohydrates and camp:
Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
→
Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2)
(modification, collaborate)
-
BioCarta chrebp regulation by carbohydrates and camp:
GPCR/g-alpha-s/g-beta/g-gamma/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNAS-GNGT1-GNB1)
→
Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2)
(modification, collaborate)
-
BioCarta ß-arrestins in gpcr desensitization:
ligand/GPCR complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3)
→
G-protein Receptor (HTR2C/ADRA1B/AGTR2/CHRM1/CCR5/PTGER1/P2RY2/CCR3/EDNRB/EDNRA/CXCR4/FPR1/ADRB2)
(degradation, collaborate)
-
BioCarta activation of camp-dependent protein kinase pka:
G-protein receptor/G-gamma/G-beta/G-alpha-S/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-GNAS)
→
G-protein receptor/G-gamma/G-beta/Ligand complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3)
(modification, collaborate)
-
BioCarta activation of camp-dependent protein kinase pka:
G-protein receptor/G-gamma/G-beta/G-alpha-S/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-GNAS)
→
Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2)
(modification, collaborate)
-
BioCarta activation of camp-dependent protein kinase pka:
G-alpha-s/GTP complex (GNAS)
→
G-protein receptor/G-gamma/G-beta/Ligand complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3)
(modification, collaborate)
-
BioCarta activation of camp-dependent protein kinase pka:
G-protein receptor/G-gamma/G-beta/Ligand complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3)
→
Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2)
(modification, collaborate)
-
BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling:
Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
→
GPCR/g-alpha-s/g-beta/g-gamma/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNAS-GNGT1-GNB1)
(modification, collaborate)
-
BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling:
Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
→
G-alpha-s/GTP complex (GNAS)
(modification, collaborate)
-
BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling:
Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
→
Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2)
(modification, collaborate)
-
BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling:
GPCR/g-alpha-s/g-beta/g-gamma/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNAS-GNGT1-GNB1)
→
Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2)
(modification, collaborate)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
atp:[beta-adrenergic-receptor] phosphotransferase (ADRBK1)
→
Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
(modification, activates)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
atp:[beta-adrenergic-receptor] phosphotransferase (ADRBK1)
→
Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
(modification, activates)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
→
Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
(modification, collaborate)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
g-gamma/g-beta complex (GNGT1-GNB1)
→
Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
(modification, collaborate)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
→
Ligand/GPCR(+)/Arrestin complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1)
(modification, collaborate)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1)
→
Arrestin (ARRB1)
(modification, collaborate)
-
KEGG Chemokine signaling pathway:
CCL1/CCL11/CCL13/CCL14/CCL15/CCL16/CCL17/CCL18/CCL19/CCL2/CCL20/CCL21/CCL22/CCL23/CCL24/CCL25/CCL26/CCL27/CCL28/CCL3/CCL3L1/CCL3L3/CCL4/CCL4L1/CCL4L2/CCL5/CCL7/CCL8/CX3CL1/CXCL1/CXCL10/CXCL11/CXCL12/CXCL13/CXCL14/CXCL16/CXCL2/CXCL3/CXCL5/CXCL6/CXCL9/IL8/PF4/PF4V1/PPBP/XCL1/XCL2
→
CCR1/CCR10/CCR2/CCR3/CCR4/CCR5/CCR6/CCR7/CCR8/CCR9/CX3CR1/CXCR1/CXCR2/CXCR3/CXCR4/CXCR5/CXCR6/XCR1
(protein-protein, activation)
-
Reactome Reaction:
CCR5
→
CXCL12
(reaction)
Lambert et al., Science signaling 2008, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994
Text-mined interactions from Literome
Schwartzkopff et al., Innate Immun 2012
(Inflammation) :
Interestingly,
CXCL4 mediated down-regulation of CCR1,
CCR2 and CCR5 was strongly dependent on the chemokine 's ability to stimulate autocrine/paracrine release of TNF-a ... Interestingly,
CXCL4 mediated down-regulation of CCR1, CCR2 and
CCR5 was strongly dependent on the chemokine 's ability to stimulate autocrine/paracrine release of TNF-a ... Culture supernatants of CXCL4 stimulated monocytes as well as chemokine enriched preparations thereof reproduced
CXCL4 induced
CCR down-regulation
Scarlatti et al., Nat Med 1997
(HIV Infections) :
Viral isolates obtained during the asymptomatic stages generally used only
CCR5 as a co-receptor and were
inhibited by RANTES, MIP-1alpha and MIP-1beta, but not by
SDF-1