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CASP3 — SERPINA1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CASP3 → SERPINA1 (directlyDecreases, SERPINA1 Activity)
  Evidence: Purified hA1AT, but not bovine serum albumin, -anti-chemotrypsin, or human 2-macroglobulin (shown to inhibit apoptosis in serum-deprived cultured smooth muscle cells14), inhibited dose dependently caspase-3 activity (Figure 5, a?c)....The enzymatic activity of recombinant human caspase-3 was measured in fluorometric assays using a specific peptide substrate, DEVD.

Text-mined interactions from Literome

Toldo et al., J Mol Cell Cardiol 2011 (Acute Disease...) : Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury
Yao et al., FEBS J 2013 (Colorectal Neoplasms) : Moreover, SERPINA3K increased the expression of FasL and activated caspase-8