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CA2 — STAR
Text-mined interactions from Literome
Manna et al., Endocrinology 1999
(Leydig Cell Tumor...) :
The potentiating
effect of
Ca2+ on the hCG stimulated
StAR response correlated with the acute progesterone ( P ) response ... The
Ca2+ effect on hCG induced
StAR mRNA expression was dramatically suppressed by 10 micromol/liter verapamil, a Ca2+ channel blocker
Spät et al., Mol Cell Endocrinol 2004
(Calcium Signaling) :
Potassium induced cytoplasmic
Ca2+ signal activates adenylyl cyclase ; induces and
activates StAR , the protein that carries cholesterol to the inner mitochondrial membrane and also enhances the expression of aldosterone synthase
Cherradi et al., Mol Endocrinol 1998
:
Similarly, while
Ca2+ induced a marked accumulation of
StAR protein in mitochondria of glomerulosa cells to 218 +/- 44 % ( n = 3 ) of controls, the presence of ANP led to a blockade of StAR protein mitochondrial import ( 113.3 +/- 15.0 % ) ... Nuclear run-on analysis showed that increases in intracellular
Ca2+ resulted in transcriptional induction of the
StAR gene and that ANP inhibited this process