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CA2 — LTB

Text-mined interactions from Literome

Gyllenhammar et al., Scand J Clin Lab Invest 1989 : Thus, LTB4 induced neutrophil Ca2+-inflow and .O2- -formation may be initiated by mechanisms similar in part to those for formylpeptides ; however it does not possess the ability to maintain this activation
Sakano et al., Cell Immunol 1988 : Stimulation of immature U937 cells with leukotriene B4 (LTB4) increased intracellular Ca2+ levels, whereas stimulation with N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) failed to increase intracellular Ca2+ levels
Goldman et al., J Immunol 1986 (Leukemia, Myeloid, Acute) : LTB4 stimulated an increase in [ Ca+2 ] in in HL-60 cell derived monocytes which reached 50 % of the maximal level at an LTB4 concentration of 0.5 nM ( EC50 ) ... Preincubation of HL-60 cell derived monocytes with 10 nM LTB4 resulted in a selective loss of high affinity receptors, as assessed by binding of [ 3H ] LTB4, and a 200-fold increase in the EC50 for stimulation by LTB4 of increases in [ Ca+2 ] in, without alterations in either the low affinity receptors for LTB4 or the responsiveness of [ Ca+2 ] in to formyl-methionyl chemotactic peptides
Krump et al., Biochem J 1995 : In this model, Ca2+ , platelet activating factor (PAF) and N-formyl-Met-Leu-Phe ( FMLP ), added alone, were unable to induce arachidonic acid release or LTB4 synthesis, as assessed by measurements of the products by MS and HPLC, respectively
Klinker et al., Biochem Pharmacol 1994 (Leukemia) : C5a- and LTB4 induced rises in cytosolic Ca2+ concentration ([Ca2+]i) were PTX-sensitive, whereas the effect of fMLP was partially PTX-insensitive ... LTB4 induced rises in [Ca2+ ] i were more sensitive towards homologous desensitization than those induced by C5a, and the effect of fMLP was resistant in this regard
Barnette et al., Biochem Pharmacol 1994 : Furthermore, we evaluated the ability of scalaradial to inhibit the increase in intracellular Ca2+ in response to fMLP, LTB4 , A23187, and thapsigargin as well as its ability to prevent either fMLP- or LTB4 mediated elevation in inositol phosphate production ( InsP ) ... Although scalaradial inhibited the mobilization of Ca2+ induced by fMLP, LTB4 , and PAF, it did not affect the maximal Ca2+ levels attained with A23187 or thapsigargin
Rediske et al., Cell Immunol 1993 : The LTB4 induced [Ca2+ ] i response exhibited ligand selectivity, with both the diastereomer 5S-12S-diHETE and the 20-COOH LTB4 inactive at 500 nM, while 20-OH LTB4 was a partial agonist with an approximate ED50 of 10 nM ... These results suggest that LTB4 stimulated an increase in [ Ca2+ ] i via interaction with a defined LTB4 receptor
Hamasaki et al., Int Arch Allergy Immunol 1996 (Leukemia, Basophilic, Acute) : The synthesis of LTC4 and LTB4 from AA in RBL-1 cell lysates in the presence of Ca2+ was inhibited by honokiol
Yokota et al., Jpn J Pharmacol 1996 : KBT-3022 ( 1 microM ), desethyl KBT-3022 ( 1-10 microM ) and CIL ( 10 microM ) but not IM significantly inhibited both neutrophil migration and the increase in [ Ca2+ ] i induced by leukotriene B4 (LTB4)
Ohd et al., Adv Exp Med Biol 1997 : Although little is known about the role of epithelial cells in inflammation, it has been shown that such cells produce the potent chemoattractant LTB4 and the proinflammatory 5-HETE in response to intracellular accumulation of Ca2+ 24
Kim et al., Arch Pharm Res 1998 (Astrocytoma...) : In addition, LTB4 induced intracellular Ca2+ release ... Intracellular Ca2+ inhibitors, such as an intracellular Ca2+ chelator ( BAPTA ) and intracellular Ca ( 2+ ) -release inhibitors ( dantrolene and TMB-8 ), significantly blocked the LTB4 induced enhancement of cell proliferation and intracellular Ca2+ release