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AKT3 — BDNF
Text-mined interactions from Literome
Bhave et al., J Neurosci 1999
:
BDNF increased phosphorylation of Akt, a target of PI 3-kinase, and NMDA also
induced Akt phosphorylation, but only after an exposure that was long enough to induce BDNF expression
Araki et al., J Neurochem 2000
:
In contrast,
BDNF induced activation of
Akt was enhanced in neurons expressing wild-type or 4F mutant BIT/SHPS-1
Mai et al., J Neurochem 2002
(Neuroblastoma) :
Overexpression of GSK3beta did not affect
BDNF induced phosphorylation of
Akt , ERK1/2, or FKHRL1, but abolished CREB phosphorylation induced by BDNF
Zhu et al., Amino Acids 2002
:
In contrast,
BDNF induced
Akt phosphorylation was abolished by K252a, but not by the addition of MK-801
Ruiz-León et al., J Neurochem 2004
(Neuroblastoma) :
Taken together, our results suggest that simultaneous activation of at least two signalling pathways, Ras/MAPK and
PI3K/Akt , is
necessary to mediate a full activation of the APP promoter by
BDNF
Gavaldà et al., Mol Cell Neurosci 2004
(MAP Kinase Signaling System) :
In the present study, we show that the stimulation of cultured striatal cells with
BDNF increased the phosphorylation of
Akt and p42/p44
Leeds et al., Neurochem Int 2005
:
BDNF , but not NT-3, treatment of immature CGC
caused a marked, but transient activation of
Akt through phosphatidylinositol (PI) 3-kinase
Li et al., Cancer Res 2005
(Neuroblastoma) :
Pharmacologic inhibition of Akt, with PIA6, a phosphatidylinositol ether lipid analogue ( PIA ), blocks
BDNF induced phosphorylation of
Akt and the downstream target of Akt
Laurino et al., J Cell Sci 2005
:
Our results show that IGF-1, but not
BDNF , significantly and rapidly
stimulates IRS/PI3K/Akt and membrane expansion
Sánchez-Pérez et al., Neurochem Int 2006
:
Brain derived neurotrophic factor (BDNF) increases phosphorylation ( and activity ) of
Akt to 350 +/- 60 % of basal and also potentiates the increase of calcium and in cGMP induced by NMDA
Soriano et al., J Neurosci 2006
(Synaptic Transmission) :
Key mediators of synaptic NMDA receptor dependent neuroprotection, phosphatidylinositol 3
kinase-Akt ( PI3 kinase-Akt ) signaling to Forkhead box subgroup O ( FOXO ) export and glycogen synthase kinase 3beta ( GSK3beta )
inhibition and cAMP response element binding protein dependent ( CREB dependent ) activation of
brain derived neurotrophic factor (BDNF) , can be induced only by low doses of NMDA via this action potential dependent route
Li et al., Cell Death Differ 2007
(Neuroblastoma) :
Previously, we found
BDNF activation of TrkB through
PI3K/Akt protects NB from etoposide/cisplatin induced cell death
Perez-Pinera et al., Mol Cell Biochem 2007
(Adenocarcinoma...) :
Interestingly, inhibition of neurotrophin receptor signaling using K252a prevents
Akt activation in
response to NGF or
BDNF , induces apoptotic cell death, and diminishes the ability of A549 cells to growth in soft agar
Yang et al., J Neurobiol 2006
:
In LAR-/- neurons,
BDNF induced
activation of TrkB, Shc,
AKT , ERK, and CREB was significantly decreased ; while in LAR transfected neurons, BDNF induced CREB activation was augmented
Yoshii et al., Nat Neurosci 2007
:
BDNF induces transport of PSD-95 to dendrites through
PI3K-AKT signaling after NMDA receptor activation
Zheng et al., J Biol Chem 2008
:
In this study, we report that blocking clathrin, dynamin, or AP2 in cultured neurons of the central nervous system inhibited
brain derived neurotrophic factor (BDNF) induced
activation of
Akt but not ERK ... Treating neurons with the clathrin inhibitor monodansylcadaverine or a peptide that blocks dynamin function specifically abrogated
Akt pathway activation in
response to
BDNF but did not affect the response of other downstream effectors or the up-regulation of immediate early genes neuropeptide Y and activity regulated cytoskeleton associated protein
Zheng et al., J Neurochem 2008
(Ion Channel Gating) :
The basal level of intracellular calcium gates the
activation of phosphoinositide
3-kinase-Akt signaling by
brain derived neurotrophic factor in cortical neurons ... We demonstrated that sub-nanomolar
BDNF significantly
induced Akt activation in developing cortical neurons ... Blocking NMDA receptors, L-type voltage gated calcium channels, and chelating extracellular calcium by EGTA failed to block
BDNF induced
Akt phosphorylation
Chaverneff et al., J Neurochem 2009
(Hypoglycemia) :
BDNF increased both
Akt and Erk phosphorylation, but pharmacological blockade of these kinase pathways ( with wortmannin and U0126, respectively ) did not reduce the Smad phosphorylation produced by the BMP7 + BDNF combination
Chen et al., Hippocampus 2009
:
The transcription and expression of hippocampal
BDNF , as well as the
activation of
Akt , a key survival signaling molecule, were measured following acute exercise, and also following short-term treatment with the norepinephrine reuptake inhibitor, reboxetine
Sun et al., Tumour Biol 2010
(Multiple Myeloma) :
Stimulation of MM cells with
BDNF led to the activation of the phosphatidylinositol 3-kinase
(PI3K)/Akt and the MEK-extracellular signal regulated protein kinase pathways
Yin et al., J Neurochem 2010
:
In this study, we report RanBPM is a novel TrkB interacting protein that contributes to
BDNF induced MAPK and
Akt activation together with neuronal morphogenesis and survival ... Over-expression of RanBPM in PC1210 cells ( PC12 cells stably over expressing TrkB ) can significantly enhance
BDNF induced MAPK and
Akt activation
Yang et al., PloS one 2010
(Brain Ischemia...) :
Further studies showed that EDC increased p-CREB and
BDNF in the CA1 region in an ERK- and
Akt dependent manner, and that cognitive outcome after GCI was preserved by EDC in an ER-dependent manner
Hwang et al., J Agric Food Chem 2011
:
Hesperetin also stimulated the activation of
Akt , ERK, and CREB as well as
induced brain derived neurotrophic factor , PPAR? coactivator 1a ( PGC-1a ), and seladin-1 ( selective Alzheimer 's disease indicator-1 ) via both ER and TrkA in the cells
Meuchel et al., Cardiovasc Res 2011
:
Both
BDNF and NT3
increased phosphorylation of
Akt and endothelial NO synthase (eNOS)
Li et al., Cancer 2011
(Brain Neoplasms...) :
In vitro
BDNF treatment
induced Akt phosphorylation and rescued cells from etoposide induced cell death in cells with high TrkB expression, but not in cells with low TrkB expression ... Pretreatment of high TrkB expressing TB3 cells with perifosine blocked
BDNF/TrkB induced
Akt phosphorylation and inhibited BDNF 's protection of TB3 cells from etoposide treatment
Li et al., Behav Brain Res 2012
:
In cultured PC-12 cells,
BDNF activated
PI3K/Akt signaling through the TrkB receptor, whereas stimulation of ILK/Akt occurred through TrkA/p75 ( NTR ) heteroreceptor
Fortin et al., J Neurosci 2012
:
Specifically,
BDNF mediated phosphorylation of threonine 308 ( T308 ) in
AKT , a known substrate of CaMKK and an upstream activator of mTOR dependent translation, was prevented by ( 1 ) pharmacological inhibition of CaMKK with STO-609, ( 2 ) overexpression of a dominant negative CaMKK, or ( 3 ) short hairpin mediated knockdown of CaMKK ... Activation of CaMKK by BDNF requires transient receptor potential canonical ( TRPC ) channels as SKF-96365, but not the NMDA receptor antagonist d-APV, prevented
BDNF induced GluA1 surface expression as well as phosphorylation of CaMKI,
AKT ( T308 ), and mTOR ... Using siRNA we confirmed the involvement of TRPC5 and TRPC6 subunits in
BDNF induced
AKT ( T308 ) phosphorylation
Gouarné et al., Br J Pharmacol 2013
:
While
BDNF activates both the
PI3K/Akt and the ERK pathway, olesoxime induced only a late activation of the ERK pathways, which did not seem to play a major role in its neuroprotection against CPT. Rather, our results favour preserved mitochondrial membrane integrity by olesoxime