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AKT1S1 — PIK3R1
Text-mined interactions from Literome
Lee et al., PloS one 2010
(Endotoxemia) :
Furthermore, in vitro cellular studies demonstrated that LPS ( lipopolysaccharide ) activation of
mTORC1-S6K still occurs in the
presence of
PI3K-Akt inhibition alone, but can be suppressed by concurrent inhibition of PI3K-Akt and MEK-ERK pathways
Willems et al., Leukemia 2012
(Leukemia, Myeloid, Acute) :
In addition, the
mTORC1 dependent
PI3K/Akt feedback
activation was fully abrogated in AZD8055 treated AML cells
Razmara et al., Cell communication and signaling : CCS 2013
:
Thus, whereas both
mTORC1 and mTORC2 are activated in a
PI3K dependent manner, different additional signaling pathways are needed