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PI3 — RAD50
Text-mined interactions from Literome
Lova et al., J Biol Chem 2003
(Second Messenger Systems) :
Two unrelated inhibitors of
phosphatidylinositol 3-kinase (PI3K) , wortmannin and LY294002, totally
prevented Rap1B activation in platelets stimulated by cross linking of FcgammaRIIA, by stimulation of the P2Y(12) receptor for ADP, or by epinephrine
Schulte et al., Exp Cell Res 2003
:
Inhibition of
phosphatidylinositol-3'-kinase (PI3K) by wortmannin
inhibited adenosine A(2B) receptor mediated ERK1/2 phosphorylation and activation of
Rap1 , without affecting CREB and p38 phosphorylation
Romano et al., Endocrinology 2006
:
Under the same conditions,
PI3K and Akt inhibition also both
increased Raf-1 kinase activity and the levels of GTP bound ( active form ) monomeric G protein
Rap1 , which suggests that a down-regulation of the ERK-1/2 cascade is induced by the PI3K/Akt signaling pathway in unstimulated cells
Schubert et al., Transfusion 2009
:
A signaling pathway contributing to platelet storage lesion development : targeting
PI3-kinase dependent
Rap1 activation slows storage induced platelet deterioration ... These results provide the first evidence for a signaling pathway mediating PSL in which
PI3-kinase dependent
Rap1 activation leads to integrin alphaIIbbeta3 activation and PLT degranulation
Gilio et al., J Biol Chem 2009
(Thrombosis) :
Furthermore,
PI3Kalpha/beta , but not PI3Kgamma,
contributed to GPVI induced
Rap1b activation and, surprisingly, also to Rap1b independent platelet activation via GPVI
Tawa et al., Circ Res 2010
(Disease Models, Animal...) :
Rap1 regulated the interaction between afadin and
phosphatidylinositol 3-kinase (PI3K) , recruitment of the afadin-PI3K complex to the leading edge, and the activation of Akt, indicating the involvement of Rap1 and afadin in the PI3K-Akt signaling pathway
Cipolla et al., Journal of thrombosis and haemostasis : JTH 2013
:
In fibrinogen-adherent platelets, both Pyk2 and
PI3Kß were
necessary for stimulation of the small GTPase
Rap1b , a regulator of cell adhesion and spreading