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GYS2 — PI3
Text-mined interactions from Literome
Egawa et al., Endocrinology 2000
(Insulin Resistance) :
Recently, we have reported that the overexpression of a membrane targeted
phosphatidylinositol (PI) 3-kinase ( p110CAAX ) stimulated p70S6 kinase, Akt, glucose transport, and Ras activation in the absence of insulin but
inhibited insulin stimulated
glycogen synthase activation and MAP kinase phosphorylation in 3T3-L1 adipocytes
Patti et al., Ann N Y Acad Sci 1999
(Diabetes Mellitus, Type 2...) :
Similarly, activation of the hexosamine pathway by infusion of glucosamine also reduces insulin stimulated phosphorylation of IRS proteins,
activation of
PI3-kinase , and activation of
glycogen synthase