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FUT1 — PDGFB
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Paradis et al., Lab Invest 2002
:
Furthermore, spontaneous activation of
HSC plated on plastic and stimulation by vascular endothelial growth factor, lipid peroxidation products ( HNE, MDA ), acetaldehyde, and
platelet derived growth factor (PDGF)-BB significantly
up-regulated CTGF mRNA expression in HSC
Breitkopf et al., Cytokine 2005
(Fibrosis) :
Stimulation of
HSC and MFB with
PDGF-BB led to down-regulation of the new isoforms, whereas TGF-beta1 upregulated PDGF-A only
Li et al., Zhonghua Gan Zang Bing Za Zhi 2005
:
Stimulation of
HSC by Aldo results in activation of EGR-1 via ERK1/2 pathway,
leading to up-regulation of
PDGF-B expression
Xue et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 2006
:
Expressions of extracellular regulated kinase (ERK) and its phosphorylation in HSC, and expressions of TGF beta1, receptor I ( TbetaR I ) and II ( TbetaR II ) and PDGF receptor beta ( PDGFR-beta ) on the surface of
HSC induced by TGF-beta1 or
PDGF-BB were detected with Western blot assay
Ogawa et al., Hepatology international 2009
:
We found that interferon a inhibited serum stimulated [ ( 3 ) H ] thymidine incorporation of HSC in a dose dependent manner, with a significant reduction at more than 100 U/ml. Interferon a also attenuated
PDGF-BB stimulated DNA synthesis of
HSC