◀ Back to TLR2
TLR2 — TLR6
Pathways - manually collected, often from reviews:
-
BioCarta toll-like receptor pathway:
TLR2/TLR6 activating compounds/TLR2/TLR6/MYD88/IRAK/CD14 complex (CD14-TLR6-TLR2-MYD88-IRAK1)
→
TRAF6
(modification, activates)
-
BioCarta toll-like receptor pathway:
CD14
→
TLR2/TLR6 activating compounds/TLR2/TLR6/MYD88/IRAK/CD14 complex (CD14-TLR6-TLR2-MYD88-IRAK1)
(modification, collaborate)
-
BioCarta toll-like receptor pathway:
CD14
→
TLR2/TLR6/MYD88/IRAK complex (IRAK1-MYD88-TLR6-TLR2)
(modification, collaborate)
-
BioCarta toll-like receptor pathway:
TLR2/TLR6 activating compounds/TLR2/TLR6/MYD88/IRAK/CD14 complex (CD14-TLR6-TLR2-MYD88-IRAK1)
→
TLR2/TLR6/MYD88/IRAK complex (IRAK1-MYD88-TLR6-TLR2)
(modification, collaborate)
-
KEGG Toll-like receptor signaling pathway:
TLR6
→
TLR2
(protein-protein, binding/association)
-
KEGG Chagas disease (American trypanosomiasis):
Complex of TLR2-TLR6
→
MYD88
(protein-protein, activation)
-
KEGG Tuberculosis:
HSPA9
→
Complex of TLR1-TLR2-TLR6
(protein-protein, activation)
-
KEGG Tuberculosis:
Complex of TLR1-TLR2-TLR6
→
MYD88
(protein-protein, activation)
-
NCI Pathway Database Endogenous TLR signaling:
TLR6 (TLR6)
→
VCAN/TLR2/TLR1 complex (TLR2-TLR1-VCAN)
(modification, collaborate)
Kim et al., Nature 2009
Evidence: physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
TLR6 (TLR6)
→
TLR2 (TLR2)
(modification, collaborate)
Kim et al., Nature 2009
Evidence: physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
TLR2/TLR6 complex (TLR2-TLR6)
→
IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, activates)
Li et al., J Immunol 2001, Kim et al., Immunity 2007
Evidence: assay
-
NCI Pathway Database Endogenous TLR signaling:
TLR2 (TLR2)
→
TLR2/TLR6 complex (TLR2-TLR6)
(modification, collaborate)
Li et al., J Immunol 2001, Kim et al., Immunity 2007
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
TLR2 (TLR2)
→
TLR6 (TLR6)
(modification, collaborate)
Li et al., J Immunol 2001, Kim et al., Immunity 2007
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
TLR2/TLR6 complex (TLR2-TLR6)
→
TLR6 (TLR6)
(modification, collaborate)
Li et al., J Immunol 2001, Kim et al., Immunity 2007
Evidence: mutant phenotype
-
Reactome Reaction:
TLR2
→
TLR6
(direct_complex)
-
Reactome Reaction:
TLR2
→
TLR6
(reaction)
Li et al., Proc Natl Acad Sci U S A 2002, Jefferies et al., J Biol Chem 2003, Kollewe et al., J Biol Chem 2004, Gray et al., J Biol Chem 2006, Cheng et al., Biochem Biophys Res Commun 2007, Kawagoe et al., J Exp Med 2007, Piao et al., J Biol Chem 2008, Kawagoe et al., Nat Immunol 2008
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ikeda et al., Immunopharmacol Immunotoxicol 2005
:
NF-kappaB activation via TLR2, TLR1/ TLR2,
TLR2/TLR6 , and TLR4/MD-2/CD14 also was enhanced by stimulation with ZWS and ZWIS
Riccioli et al., J Immunol 2006
:
In addition,
TLR2/TLR6 and TLR5 stimulation
induces increased
ICAM-1 expression in Sertoli cells
Wu et al., Int J Immunogenet 2008
:
As an important member of TLRs,
TLR1 is
involved in the recognition of triacylated lipoproteins and mycobacterial products by binding to
TLR2 to form a heterodimer
Aravalli et al., Journal of neuroinflammation 2008
(Histoplasmosis) :
Furthermore, Yps3p induced
TLR2 signaling was
suppressed by vaccinia virus encoded
TLR inhibitors
Regueiro et al., Infect Immun 2009
:
We showed that Klebsiella induced
TLR2 and TLR4 upregulation was
dependent on
TLR activation
So et al., Glia 2009
(Cardiovirus Infections) :
More importantly,
TLR3 was
required for TMEV induced early
TLR2 upregulation in primary astrocytes leading to the production of TLR2 dependent cytokines such as IL-6
Chamorro et al., J Immunol 2009
:
TLR triggering on tolerogenic dendritic cells
results in
TLR2 up-regulation and a reduced proinflammatory immune program
Messlik et al., J Proteome Res 2009
(Chronic Disease...) :
The aim of this study was to characterize the
role of
TLR2 or TLR4 deficiency in epithelial cell stress responses under noninflamed and inflamed conditions using TLR-deficient mice and
TLR ( -/- ) cross bred IL-10-deficient mice as a model for genetically driven experimental colitis
Hamoudi et al., Leukemia 2010
(Lymphoma, B-Cell, Marginal Zone...) :
Finally, expression of
TLR6 , in the
presence of
TLR2 , enhanced both API2-MALT1 and BCL10 mediated NF-kappaB activation in vitro
Dasu et al., Am J Physiol Endocrinol Metab 2011
(Diabetes Mellitus, Type 2...) :
Moreover, data from transient transfection experiments suggest that
TLR6 is
required for
TLR2 and MD2 for TLR4 to augment inflammation in FFA- and glucose exposed cells
Stridh et al., Journal of neuroinflammation 2011
(Hypoxia-Ischemia, Brain) :
In contrast,
TLR-2 was constitutively expressed in the brain and
TLR-2 deficiency
reduced HI injury
Charavaryamath et al., Gut microbes 2011
:
Finally,
Toll-like receptor (TLR)-4 expression was decreased but
TLR-5 and -6 expression
increased in ileal segments
Kim et al., FEMS Microbiol Lett 2012
(Inflammation) :
L. plantarum genomic DNA mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of
toll-like receptor (TLR) 2 , TLR4, and TLR9 and the induction of interleukin-1 receptor associated kinase M, a negative
regulator of
TLR
Jia et al., Shanghai Kou Qiang Yi Xue 2011
:
CD14,
TLR4 receptors are involved in P.e-LPS effect and CD14,
TLR2 and TLR4 receptors are
involved in P.g-LPS effect in mouse osteoblast
Kumar et al., PloS one 2012
(Infection...) :
Moreover, stimulation of the Muller glia with
TLR 2 , 3, 4, 5, 7 and 9 agonists
resulted in an increased
TLR expression as assayed by Western blot and flow cytometry
Khan et al., Peptides 2012
(Reperfusion Injury) :
TLR2 increased 162 fold, followed by Fas associated death domain ( 37 fold ) and
TLR6 ( 24 fold ), while ubiquitin conjugating enzyme E2 variant 1 ( UBE2V1 ) decreased 55 fold
Wang et al., PloS one 2012
(Cell Transformation, Neoplastic...) :
TLR2 : TLR6 complexes
mediate the effect of NF-?B inactivation by CDA-2 ...
TLR2 :
TLR6 complexes
mediate the effect of NF-?B inactivation by CDA-2
Feriotti et al., PloS one 2013
(Disease Susceptibility...) :
Mannan or P. brasiliensis
induced decreased expression of MR and
TLR2 on A/J macrophages, whereas CR3,
TLR4 and TLR2 were reduced on B10.A cells