Gene interactions and pathways from curated databases and text-mining

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TLR2 — TLR6

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ikeda et al., Immunopharmacol Immunotoxicol 2005 : NF-kappaB activation via TLR2, TLR1/ TLR2, TLR2/TLR6 , and TLR4/MD-2/CD14 also was enhanced by stimulation with ZWS and ZWIS
Riccioli et al., J Immunol 2006 : In addition, TLR2/TLR6 and TLR5 stimulation induces increased ICAM-1 expression in Sertoli cells
Wu et al., Int J Immunogenet 2008 : As an important member of TLRs, TLR1 is involved in the recognition of triacylated lipoproteins and mycobacterial products by binding to TLR2 to form a heterodimer
Aravalli et al., Journal of neuroinflammation 2008 (Histoplasmosis) : Furthermore, Yps3p induced TLR2 signaling was suppressed by vaccinia virus encoded TLR inhibitors
Regueiro et al., Infect Immun 2009 : We showed that Klebsiella induced TLR2 and TLR4 upregulation was dependent on TLR activation
So et al., Glia 2009 (Cardiovirus Infections) : More importantly, TLR3 was required for TMEV induced early TLR2 upregulation in primary astrocytes leading to the production of TLR2 dependent cytokines such as IL-6
Chamorro et al., J Immunol 2009 : TLR triggering on tolerogenic dendritic cells results in TLR2 up-regulation and a reduced proinflammatory immune program
Messlik et al., J Proteome Res 2009 (Chronic Disease...) : The aim of this study was to characterize the role of TLR2 or TLR4 deficiency in epithelial cell stress responses under noninflamed and inflamed conditions using TLR-deficient mice and TLR ( -/- ) cross bred IL-10-deficient mice as a model for genetically driven experimental colitis
Hamoudi et al., Leukemia 2010 (Lymphoma, B-Cell, Marginal Zone...) : Finally, expression of TLR6 , in the presence of TLR2 , enhanced both API2-MALT1 and BCL10 mediated NF-kappaB activation in vitro
Dasu et al., Am J Physiol Endocrinol Metab 2011 (Diabetes Mellitus, Type 2...) : Moreover, data from transient transfection experiments suggest that TLR6 is required for TLR2 and MD2 for TLR4 to augment inflammation in FFA- and glucose exposed cells
Stridh et al., Journal of neuroinflammation 2011 (Hypoxia-Ischemia, Brain) : In contrast, TLR-2 was constitutively expressed in the brain and TLR-2 deficiency reduced HI injury
Charavaryamath et al., Gut microbes 2011 : Finally, Toll-like receptor (TLR)-4 expression was decreased but TLR-5 and -6 expression increased in ileal segments
Kim et al., FEMS Microbiol Lett 2012 (Inflammation) : L. plantarum genomic DNA mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of toll-like receptor (TLR) 2 , TLR4, and TLR9 and the induction of interleukin-1 receptor associated kinase M, a negative regulator of TLR
Jia et al., Shanghai Kou Qiang Yi Xue 2011 : CD14, TLR4 receptors are involved in P.e-LPS effect and CD14, TLR2 and TLR4 receptors are involved in P.g-LPS effect in mouse osteoblast
Kumar et al., PloS one 2012 (Infection...) : Moreover, stimulation of the Muller glia with TLR 2 , 3, 4, 5, 7 and 9 agonists resulted in an increased TLR expression as assayed by Western blot and flow cytometry
Khan et al., Peptides 2012 (Reperfusion Injury) : TLR2 increased 162 fold, followed by Fas associated death domain ( 37 fold ) and TLR6 ( 24 fold ), while ubiquitin conjugating enzyme E2 variant 1 ( UBE2V1 ) decreased 55 fold
Wang et al., PloS one 2012 (Cell Transformation, Neoplastic...) : TLR2 : TLR6 complexes mediate the effect of NF-?B inactivation by CDA-2 ... TLR2 : TLR6 complexes mediate the effect of NF-?B inactivation by CDA-2
Feriotti et al., PloS one 2013 (Disease Susceptibility...) : Mannan or P. brasiliensis induced decreased expression of MR and TLR2 on A/J macrophages, whereas CR3, TLR4 and TLR2 were reduced on B10.A cells