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LTA — TLR2

Text-mined interactions from Literome

Schwandner et al., J Biol Chem 1999 : In contrast to LPS signaling, activation of TLR2 by sPGN and LTA does not require serum
Jacinto et al., J Immunol 2002 : Correspondingly, stimulation of TLR2 by LTA , although activating IRAK, does not cause IRAK degradation
Morath et al., J Exp Med 2002 : In contrast to Gram negative lipopolysaccharides, this LTA requires the toll-like receptor (TLR)-2 and not TLR-4 for cytokine induction in monocytes and macrophages
Han et al., Infect Immun 2003 : Excess teichoic acid, LTA-0 , antibodies to phosphocholine, or antibodies to TLR4 did not inhibit the LTA induced TLR2 stimulation
Møller et al., Cytokine 2005 : E. coli-LPS and LTA induced a dose dependent increase of CD14, TLR2 and TLR4 expression on monocytes in whole blood ... E. coli-LPS and LTA induced a dose dependent increase of CD14, TLR2 and TLR4 expression on monocytes in whole blood
Durand et al., J Immunol 2006 : LTA up-regulated the expression of its own receptor TLR2 , as well as the production of several chemokines
Deininger et al., Clinical and vaccine immunology : CVI 2007 : LTA , which activates Toll-like receptor 2 (TLR2) , induces a unique cytokine and chemokine pattern
Yang et al., Mol Immunol 2008 (Escherichia coli Infections...) : LTA prepared from the S. aureus strain used to infect the cows activates the bovine TLR2 as strongly as the entire, heat killed pathogen
Henneke et al., J Immunol 2008 (Sepsis) : Several lines of genetic and biochemical evidence indicated that lipoteichoic acid (LTA) , the most widely studied TLR2 agonist in Gram positive bacteria, was not essential for TLR2 activation
Zorko et al., J Antimicrob Chemother 2008 : Both compounds prevent cell activation of TLR4 and TLR2 by LPS and LTA , respectively
Lee et al., J Endod 2009 : Furthermore, CHX abrogated the ability of LTA to stimulate Toll-like receptor 2 , resulting in the attenuated induction of TNF-alpha expression
Mrabet-Dahbi et al., Exp Dermatol 2009 : Activation by various TLR2 ligands only induces the selective release of cytokines in peritoneum derived cultured mast cells ( PCMCs ) with preferential secretion of pro-inflammatory cytokines ( IL-6 > IL-17 > IFN-gamma TNF > IL-1 > GM-CSF ) upon stimulation with lipoteichoic acid (LTA)
Yang et al., J Leukoc Biol 2009 (Bone Resorption) : TLR2 , known to recognize LTA, might be essential for the LTA inhibition of osteoclastogenesis, as the inhibition did not occur in the precursors from TLR2-deficient mice
Lee et al., Am J Pathol 2010 (Inflammation) : Furthermore, LTA could stimulate TLR2 , MyD88, PI3K, and Rac1 complex formation
Nerren et al., Vet Immunol Immunopathol 2010 (Poultry Diseases) : The aim of the present study was to gain better insight into the nature of the ligand for TLR15 by characterizing gene expression patterns of TLR15 by heterophils in response to numerous bacterial derived TLR agonists LPS, flagellin, CpG oligodeoxynucleotides, lipotechoic acid (LTA) , peptidoglycan ( PGN ), and Pam3CSK4 (PAM), stimulation with live Salmonella enterica serovar Enteritidis ( SE-used as a positive control ), chicken isolates of Escherichia coli ( EC ) and Enterococcus gallinarum ( EG ), the equine-specific pathogen Rhodococcus equi, and stimulation with heat killed, and formalin killed SE, EC, and EG
Lew et al., Annals of dermatology 2009 : Cultured human epidermal keratinocytes constitutively expressed TLR2 and the expression was stimulated by LTA and SLO ; in addition, IFN-gamma and TNF-alpha upregulated TLR2 expression
Niebuhr et al., Exp Dermatol 2011 (Dermatitis, Atopic) : The aim of this study was to investigate intrinsic TLR-2 expression and cytokine secretion upon TLR-2 stimulation with peptidoglycan ( PGN ), lipoteichoic acid (LTA) and N-palmitoyl-S- [ 2,3-bis ( palmitoyl ) - ( 2RS ) -propyl ] - ( R ) cysteinyl-alanyl-glycine ( Pam3Cys ) in keratinocytes from patients with AD compared to healthy controls
Long et al., Proc Natl Acad Sci U S A 2011 : The inhibitory capacity of LTA and these modified ligands requires the expression of TLR2 , but is independent of the TLR2 signaling adaptor, MyD88
Fargues et al., Bull Group Int Rech Sci Stomatol Odontol 2010 : We provide here additional data showing the fine localization of NOD2 in healthy dental pulps, as well as differential regulation of TLR2, TLR4 , NOD2, CCL2 and CXCL8 genes by LTA and the synthetic TLR2 agonists Pam2CSK4 and Pam3CSK4 ... We provide here additional data showing the fine localization of NOD2 in healthy dental pulps, as well as differential regulation of TLR2 , TLR4, NOD2, CCL2 and CXCL8 genes by LTA and the synthetic TLR2 agonists Pam2CSK4 and Pam3CSK4