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CD14 — TLR2

Pathways - manually collected, often from reviews:

• BioCarta toll-like receptor pathway: TLR2/TLR6 activating compounds/TLR2/TLR6/MYD88/IRAK/CD14 complex (CD14-TLR6-TLR2-MYD88-IRAK1) → TRAF6 (modification, activates)
• BioCarta toll-like receptor pathway: TLR2/TLR6 activating compounds/TLR2/TLR2/MYD88/IRAK/CD14 complex (MYD88-IRAK1-CD14-TLR2) → TRAF6 (modification, activates)
• BioCarta toll-like receptor pathway: CD14 → TLR2/TLR6 activating compounds/TLR2/TLR6/MYD88/IRAK/CD14 complex (CD14-TLR6-TLR2-MYD88-IRAK1) (modification, collaborate)
  
• BioCarta toll-like receptor pathway: CD14 → TLR2/TLR6/MYD88/IRAK complex (IRAK1-MYD88-TLR6-TLR2) (modification, collaborate)
  
• BioCarta toll-like receptor pathway: TLR2/TLR6 activating compounds/TLR2/TLR6/MYD88/IRAK/CD14 complex (CD14-TLR6-TLR2-MYD88-IRAK1) → TLR2/TLR6/MYD88/IRAK complex (IRAK1-MYD88-TLR6-TLR2) (modification, collaborate)
  
• BioCarta toll-like receptor pathway: CD14 → TLR2/TLR6 activating compounds/TLR2/TLR2/MYD88/IRAK/CD14 complex (MYD88-IRAK1-CD14-TLR2) (modification, collaborate)
  
• BioCarta toll-like receptor pathway: CD14 → TLR2/TLR2/MYD88/IRAK complex (MYD88-IRAK1-TLR2) (modification, collaborate)
  
• BioCarta toll-like receptor pathway: TLR2/TLR6 activating compounds/TLR2/TLR2/MYD88/IRAK/CD14 complex (MYD88-IRAK1-CD14-TLR2) → TLR2/TLR2/MYD88/IRAK complex (MYD88-IRAK1-TLR2) (modification, collaborate)
  
• KEGG Amoebiasis: Complex of CD14-TLR2-TLR4 → NFKB1/RELA (protein-protein, activation)
• KEGG Tuberculosis: CD14 → TLR2 (protein-protein, activation)
• NCI Pathway Database Endogenous TLR signaling: CD14 (CD14) → TLR2/MD2 complex (LY96-TLR2) (modification, activates)
  Schaefer et al., J Clin Invest 2005
  Evidence: physical interaction
• NCI Pathway Database Endogenous TLR signaling: CD14 (CD14) → BGN/TLR2/TLR1/MD2 (dimer) complex (TLR2-TLR1-LY96-BGN) (modification, activates)
  Schaefer et al., J Clin Invest 2005
  Evidence: physical interaction
• NCI Pathway Database Endogenous TLR signaling: CD14 (CD14) → VCAN/TLR2/TLR1 complex (TLR2-TLR1-VCAN) (modification, activates)
  Kim et al., Nature 2009
  Evidence: physical interaction
• NCI Pathway Database Endogenous TLR signaling: CD14 (CD14) → TLR2 (TLR2) (modification, activates) Kim et al., Nature 2009
  Evidence: physical interaction
• Reactome Reaction: CD14 → TLR2 (reaction) Schwandner et al., J Biol Chem 1999*, Aliprantis et al., Science 1999*, Means et al., J Immunol 1999*, Takeuchi et al., Immunity 1999*, Hajjar et al., J Immunol 2001*, Li et al., Proc Natl Acad Sci U S A 2002, Jefferies et al., J Biol Chem 2003, Kollewe et al., J Biol Chem 2004, Okusawa et al., Infect Immun 2004*, Beutler et al., Nature 2004*, Gray et al., J Biol Chem 2006, Massari et al., J Immunol 2006*, Cheng et al., Biochem Biophys Res Commun 2007, Kawagoe et al., J Exp Med 2007, Piao et al., J Biol Chem 2008, Kawagoe et al., Nat Immunol 2008
• Reactome Reaction: CD14 → TLR2 (indirect_complex) Schwandner et al., J Biol Chem 1999*, Aliprantis et al., Science 1999*, Means et al., J Immunol 1999*, Takeuchi et al., Immunity 1999*, Hajjar et al., J Immunol 2001*, Okusawa et al., Infect Immun 2004*, Beutler et al., Nature 2004*, Massari et al., J Immunol 2006*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TLR2 — CD14 (physical association, affinity chromatography technology) Yang et al., J Immunol 1999*
• IRef Dip Interaction: TLR2 — CD14 (direct interaction, fluorescent resonance energy transfer) Hajishengallis et al., Proc Natl Acad Sci U S A 2008*
• IRef Hprd Interaction: TLR2 — CD14 (in vivo) Yang et al., J Immunol 1999*
• IRef Ophid Interaction: TLR2 — CD14 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Muta et al., Eur J Biochem 2001 : Essential roles of CD14 and lipopolysaccharide binding protein for activation of toll-like receptor (TLR)2 as well as TLR4 Reconstitution of TLR2- and TLR4-activation by distinguishable ligands in LPS preparations
Farnell et al., Dev Comp Immunol 2003 : Oxidative burst mediated by toll like receptors ( TLR ) and CD14 on avian heterophils stimulated with bacterial toll agonists
Oshikawa et al., Biochem Biophys Res Commun 2003 (Lung Diseases) : The results demonstrated three patterns of gene expression : the TLR2 and myeloid differentiation factor 88 ( MyD88 ) gene expressions were induced in AM in response to lipopolysaccharide (LPS), interleukin (IL)-1beta, or tumor necrosis factor-alpha or in the lung tissue of an LPS induced acute lung injury model ; the gene expressions of TLR1, -3, -6, CD14 , and MD2 were unchanged ; and the TLR4 and TLR5 gene expressions were downregulated in AM following inflammatory stimuli
Lucarelli et al., Eur Cytokine Netw 2004 : On the other hand, TLR9 expression was decreased by SiO ( 2 ) nano-particles, and expression of the co-receptor CD14 was inhibited by Co nanoparticles
Büchau et al., J Invest Dermatol 2008 : We observed that pimecrolimus enhances distinct expression of cathelicidin, CD14 , and human beta-defensin-2 and beta-defensin-3 in response to TLR2/6 ligands
Roncon-Albuquerque et al., Life Sci 2008 (Fatty Liver...) : These results suggest that CD14 mediated TLR activation might contribute to the cardiovascular and metabolic complications of obesity
Jia et al., Shanghai Kou Qiang Yi Xue 2011 : CD14, TLR4 receptors are involved in P.e-LPS effect and CD14 , TLR2 and TLR4 receptors are involved in P.g-LPS effect in mouse osteoblast
Lei et al., J Med Primatol 2013 : Toll-like receptor ( TLR ) stimulation significantly increased IDO protein level in CD14 ( + ), CD56 ( + ), CD1c ( + ), CD11c ( + ), and CD123 ( + ) myeloid cells