Wilson et al., Atherosclerosis 2002
:
Because OPN is involved in ECM/integrin signaling, and may participate in proliferative control, the proliferation profiles of control and allylamine vSMCs seeded on different matrices were compared
Goessler et al., Int J Mol Med 2008
:
Particularly, the receptors for fibronectin, vitronectin, osteopontin and the collagens may be involved in the generation of the ECM Singh et al., J Mol Cell Cardiol 2010
(Myocardial Infarction) :
This review summarizes -- 1 ) signaling pathways leading to increased expression of OPN in the heart ; 2 ) the alterations in the structure and function of the heart post-MI in mice lacking OPN ; and 3 ) mechanisms involved in OPN mediated ECM remodeling post-MI