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RAC1 — S1PR3

Pathways - manually collected, often from reviews:

• NCI Pathway Database S1P3 pathway: RAC1/GDP complex (RAC1) → S1P/S1P3/Gi complex (S1PR3-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1) (modification, collaborate)
  Paik et al., J Biol Chem 2001
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Takuwa et al., Biochim Biophys Acta 2002 : Consistent with this, Edg1 and Edg3 , and Edg5 regulate the activity of the Rho family GTPase Rac positively and negatively, respectively
Sugimoto et al., Mol Cell Biol 2003 : In contrast to S1P2, S1P3 mediated S1P directed, pertussis toxin-sensitive chemotaxis and Rac activation despite concurrent stimulation of Rho via G12/13 ... Upon inactivation of Gi by pertussis toxin, S1P3 mediated inhibition of Rac and migration just like S1P2
Takuwa et al., American journal of cancer research 2011 : S1PR1 and S1PR3 mediate directed cell migration toward S1P through coupling to G ( i ) and activating Rac , a Rho family small G protein essential for cell migration ... In sharp contrast, S1PR2 mediates S1P inhibition of Rac at the site downstream of G ( 12/13 ) -mediated Rho activation, thus identified as the first G protein coupled receptor that negatively regulates Rac and cell migration