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IGF1 — RAC1
Text-mined interactions from Literome
Okamoto et al., Mol Cell Biol 2000
:
Both S1P and
IGF I induced a biphasic increase in the amount of the GTP bound active form of
Rac ... In EDG5 cells, S1P stimulated PI 3-kinase activity as it did in EDG1 cells but inhibited the basal Rac activity and totally abolished
IGF I-induced Rac activation, which
involved stimulation of
Rac-GTPase activating protein activity rather than inhibition of Rac-guanine nucleotide exchange activity
Nagasawa et al., Biochem J 2005
:
EP2 stimulation failed to inhibit tyrosine phosphorylation either of IGF-I receptor or IRS-1 ( insulin receptor substrate-1 ), or activation of phosphoinositide 3-kinase or Akt in response to IGF-I, but potently and dose-dependently inhibited
IGF-I induced
activation of cellular
Rac activity and membrane ruffling ... The inhibitory effects of PGE2 on
IGF-I induced chemotaxis, membrane ruffling and
Rac activation were faithfully reproduced by a low concentration of forskolin, which induced a comparable extent of cAMP elevation as with 10 ( -8 ) M PGE2, and were potentiated by isobutylmethylxanthine
Ceacareanu et al., Am J Physiol Cell Physiol 2006
:
The present study was performed to investigate the hypotheses that 1 )
IGF-I increases the activity of the small GTPase
Rac1 as well as H(2)O ( 2 ) levels and 2 ) NO suppresses IGF-I induced H ( 2 ) O ( 2 ) elevation by decreasing Rac1 activity via increased PTP-PEST activity and dephosphorylation of p130 ( cas ) ... We report that
IGF-I induces phosphorylation of p130 ( cas ) and activation of
Rac1 and that NO attenuates these effects
Meng et al., Cardiovasc Res 2008
:
Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and
Rac1 in vascular smooth muscle cells ...
IGF-I induced the activation of
Rac1 ... Knockdown of Nox4 did not affect
IGF-I induced activation of
Rac1
Morimura et al., International journal of cell biology 2011
:
In noninvasive breast cancer MCF7 cells, no lamellipodia were
induced by
IGF-I , whereas in MDA-MB-231 cells,
Rac1 , stathmin, and EB1 were overexpressed