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MDM2 — NPM1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MDM2 — NPM1 (physical association, affinity chromatography technology) Kurki et al., Cancer Cell 2004*
• IRef Biogrid Interaction: MDM2 — NPM1 (direct interaction, pull down) Kurki et al., Cancer Cell 2004*
• IRef Biogrid Interaction: MDM2 — NPM1 (direct interaction, unspecified method) Nicholson et al., J Proteome Res 2012*
• IRef Biogrid Interaction: MDM2 — NPM1 (physical association, affinity chromatography technology) Nicholson et al., J Proteome Res 2012*
• IRef Hprd Interaction: NPM1 — MDM2 (in vivo) Kurki et al., Cancer Cell 2004*
• IRef Hprd Interaction: NPM1 — MDM2 (in vitro) Kurki et al., Cancer Cell 2004*
• IRef Intact Interaction: MDM2 — NPM1 (physical association, anti bait coimmunoprecipitation) Kurki et al., Cancer Cell 2004*
• IRef Intact Interaction: MDM2 — NPM1 (physical association, pull down) Kurki et al., Cancer Cell 2004*
• IRef Intact Interaction: MDM2 — NPM1 (direct interaction, pull down) Ji et al., EMBO Rep 2012*
• IRef Intact Interaction: Complex of MDM2-TP53-NPM1-NPM1 (association, anti bait coimmunoprecipitation) Kurki et al., Cancer Cell 2004*
• IRef Intact Interaction: Complex of TP53-MDM2-NPM1 (association, anti bait coimmunoprecipitation) Ji et al., EMBO Rep 2012*

Text-mined interactions from Literome

Kurki et al., Cancer Cell 2004 (Osteosarcoma) : Here we show that NPM is a UV damage response protein that undergoes nucleoplasmic redistribution and regulates p53 and HDM2 levels and their interaction
Ando et al., J Biol Chem 2013 : Our data suggest that enhanced HDM2 expression induced by mutant NPM1 may have a role in MEF/ELF4 dependent leukemogenesis