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IL1A — NOX4
Text-mined interactions from Literome
Katsuyama et al., Endocrinology 1999
:
Both
interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha potently
stimulated nitrite/nitrate (
NOx ) production with a concomitant expression of iNOS mRNA and protein as demonstrated by Northern and Western blot analysis, respectively
Tojo et al., J Hypertens 2005
(Hypertension, Renal) :
Nicotinamide adenine dinucleotide phosphate (
NAD ( P ) H ) oxidase is
regulated by angiotensin II,
interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha via p38 mitogen activated protein kinase ( MAPK )
Moe et al., J Cell Mol Med 2011
(Ventricular Remodeling) :
Nox2 and Nox4 siRNA were used to determine whether or not Nox2 and
Nox4 mediated TNF-a induced ROS and upregulation of
IL-1ß and IL-6 in adult human cardiomyocytes ...
Nox2 and Nox4 siRNA significantly
attenuated TNF-a induced ROS and upregulation of
IL-1ß and IL-6 in cardiomyocytes
Yoshimura et al., J Biol Chem 2011
:
Mct-1 knockdown also prevented
IL-1ß induced expression of phagocyte-type
NADPH oxidase ( NOX-2 ), an enzyme specialized for production of ROS, whereas it did not have an effect on inducible NO synthase
Donini et al., Prostate 2012
(Prostatic Neoplasms) :
LNCaP
enhance IL-1ß , IL-23, IL-6, and TNF-a secretion by decreasing glucan dependent NADPH oxidase activity, whereas glucan increases IL-12 production through
NADPH oxidase unrelated mechanisms
Pang et al., Journal of neuroinflammation 2012
(MAP Kinase Signaling System) :
Telmisartan reduced the
IL-1ß induced increase in IL-1R1 receptor and NADPH oxidase-4 (NOX-4) mRNA expression,
NADPH oxidase activity, and ROS generation, and reduced hydrogen peroxide induced COX-2 gene expression
Kanno et al., Am J Physiol 1994
:
Among several cytokines and bacterial lipopolysaccharide tested,
IL-1 beta most effectively
stimulated NOx production