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MAP2K6 — TGFB1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAP2K6
→
TGFB1
(increases, TGFB1 Activity)
Evidence: up-regulation of BGN mRNA was preceded by a delayed increase in the phosphorylation of p38 and its upstream activator MKK6 in TGF-beta 1-treated PANC-1 cells,
Text-mined interactions from Literome
Kivinen et al., Cell Growth Differ 1999
:
Ras- and
mitogen activated protein kinase kinase dependent and -independent pathways in p21Cip1/Waf1 induction by fibroblast growth factor-2, platelet derived growth factor, and
transforming growth factor-beta1
Ogihara et al., J Biol Chem 2003
:
Instead, activin A and HGF activation was inhibited by overexpression of a dominant negative mutant of
transforming growth factor-beta activated kinase 1 ( TAK1 ), or
mitogen activated protein kinase kinase 3 ( MKK3 ), or by treatment with a p38 MAPK-specific inhibitor, SB203580