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MAP2K6 — SMAD7

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAP2K6 → SMAD7 (increases) Edlund et al., Mol Biol Cell 2003
  Evidence: Treatement of antisense Smad7 (AS-S7) transfected PC-3U cells with TGF-beta1 for 15 min to 24 hour did not lead to phosphorylation of MKK3/6 whereas a stronger signal for phosphorylated MKK3/6 was observed in lysates from PC-3U cells infected with adenoviral Flag-Smad7.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAP2K6 — SMAD7 (physical association, affinity chromatography technology) Edlund et al., Mol Biol Cell 2003
• IRef Hprd Interaction: SMAD7 — MAP2K6 (in vivo) Edlund et al., Mol Biol Cell 2003
• IRef Ophid Interaction: SMAD7 — MAP2K6 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: SMAD7 — MAP2K6 (aggregation, confirmational text mining) Edlund et al., Mol Biol Cell 2003

Text-mined interactions from Literome

Edlund et al., Mol Biol Cell 2003 (Prostatic Neoplasms) : Transforming growth factor-beta1 ( TGF-beta ) -induced apoptosis of prostate cancer cells involves Smad7 dependent activation of p38 by TGF-beta activated kinase 1 and mitogen activated protein kinase kinase 3
Chen et al., Exp Cell Res 2010 : Inhibition of mitogen activated protein kinase kinase 1 ( MEK 1 ) either directly with PD98059 or with MEK 1 siRNA resulted in inhibition of EPO mediated suppression of EMT and Smad signal transduction in TGF-beta1 treated cells