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IL1A — MMP9

Text-mined interactions from Literome

Bargagna-Mohan et al., Invest Ophthalmol Vis Sci 1999 : Regulation of gelatinase B production in corneal cells is independent of autocrine IL-1alpha ... However, it is further demonstrated that these two events are not dependent on one another but occur in parallel : IL-1alpha does not regulate gelatinase B production ( synthesis ), nor was there evidence that any other secreted autocrine cytokine acts as mediator
Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Lotz et al., Rheum Dis Clin North Am 1999 (Arthritis...) : NO also may be involved as a mediator of IL-1 induced expression of MMP , mRNA, and protein and may contribute as an activator of the latent forms of the enzymes
van Meurs et al., J Immunol 1999 (Arthritis...) : In vitro studies showed that SLN-1 is also pivotally involved in IL-1 induced MMP activity
Kubota et al., J Dent Res 2000 (Dentigerous Cyst...) : Interleukin-1alpha dependent regulation of matrix metalloproteinase-9(MMP-9) secretion and activation in the epithelial cells of odontogenic jaw cysts ... In this study, we investigated the effects of IL-1alpha on the secretion and activation of MMP-9 in odontogenic jaw cysts
Origuchi et al., Clin Exp Rheumatol 2000 (Arthritis, Rheumatoid) : In support of this result, IL-1 beta stimulation induced the expression of membrane type matrix-metalloproteinase ( MT-MMP ), a newly identified MMP-2 specific activator, in rheumatoid osteoblasts
Shlopov et al., J Rheumatol 2001 (Osteoarthritis) : A decrease in IL-1alpha , IL-1beta, and IL-6 would reduce stimulation of MMP production, while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves
Ijima et al., Eur J Oral Sci 2001 : IL-1alpha significantly induced an increase of active MMP9 as well as pro- and active MMP3, but had no effect on the MMP2 activity in both types of cells ... MMP3 and MMP9 mRNAs were also inducible in these cells by IL-1alpha stimulation
Miyajima et al., Microb Pathog 2001 (Corneal Ulcer...) : Effects of pseudomonal virulence factors [ elastase, alkaline protease, exotoxin A and lipopolysaccharide (LPS) ], tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta on MMP induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ), zymography and immunoblotting
Estève et al., J Biol Chem 2002 (Glioma) : Here we report that the atypical PKC-zeta isoform participates in the induction of MMP-9 expression by interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) in rat C6 glioma cells
Estève et al., Biochem Biophys Res Commun 2002 : Here, we report that PI 3-kinase inhibits MMP-9 expression induced by either IL-1 or TNF-alpha in rat C6 glioma cells ... Furthermore, stable C6 clones over expressing the dominant negative form the regulatory subunit of PI 3-kinase potentiated the expression of MMP-9 induced by IL-1 or TNF-alpha
Elliott et al., Arthritis Res Ther 2003 (Bone Neoplasms...) : To quantify the effects of CDDO on IL-1 induced MMP-1, MMP-13 and Bcl-3 expression, we stimulated the chondrosarcoma cell line SW-1353 and human primary chondrocytes with IL-1, in the presence or absence of CDDO
Fuse et al., Lymphokine Cytokine Res 1992 (Cell Transformation, Neoplastic...) : The induction of IL-6 and gelatinase B by IL-1 in mouse cell lines transformed with bovine papillomavirus : decreased production in tumorigenic cells
Lorenzo et al., Matrix 1992 : IL-1 , TNF, PTH and TPA all increased 92-kDa gelatinase activity in the CM of the bone cultures by about 2- to 2.5-fold
Kaden et al., Atherosclerosis 2003 (Aortic Valve Stenosis) : As recent studies have suggested that calcific AS might result from an inflammatory process involving leukocyte invasion and activation, the present study aimed to elucidate the role of the pro-inflammatory cytokine interleukin (IL)-1 beta on MMP expression and cell proliferation in human aortic valves
Lee et al., J Biomed Sci 2003 (Liver Cirrhosis) : Differential role of p38 in IL-1alpha induction of MMP-9 and MMP-13 in an established liver myofibroblast cell line ... Recombinant IL-1alpha upregulated the expression of both MMP-9 and -13, and the induction of MMP-13 but not MMP-9 could be inhibited by SB203580, an inhibitor of p38
Smith et al., Br J Ophthalmol 2004 : IL-1alpha and LPS had no effect on MMP/TIMP production by cultured corneal epithelial cells and keratocytes
Chang et al., J Periodontal Res 2004 (MAP Kinase Signaling System...) : Our findings demonstrated that IL-1alpha and P. gingivalis enhance MMP-9 production in human osteosarcoma cells, and the signal transduction pathways p38, MEK, and PI3K are involved in the inhibition of MMP-9
Dayer et al., Reumatismo 2004 (Arthritis, Rheumatoid) : IL-1 and TNF-alpha are potent inducers of matrix metalloproteinases ( MMP ) , eicosanoids, nitric oxide oxydase ( iNOS ), receptor activator of NF-kB ligand ( RANKL ), products involved in the destruction of the extracellular matrix, the cartilage and in bone resorption
Kobayashi et al., Arthritis Rheum 2005 (Osteoarthritis, Knee) : Independent analyses of gene expression in cultured cartilage from 9 other OA patients revealed that IL-1 or TNFalpha blockade, either alone and/or in combination, frequently down-regulated MMP-1, MMP-3 , and MMP-13 expression
Turner et al., FASEB J 2005 : Simvastatin reduced TPA- and PDGF/IL-1 induced MMP-9 secretion and mRNA levels, effects reversed by geranylgeranyl pyrophosphate and mimicked by inhibiting Rho geranylgeranylation or Rho-kinase ( ROCK ) ... MMP-9 secretion induced by PDGF/IL-1 was mediated via the ERK, p38 MAPK, and NFkappaB pathways, whereas that induced by TPA was mediated specifically via the ERK pathway
Han et al., Surgery 2005 (Skin Diseases) : In contrast, IL-1 induced activation of pro-MMP-9 was a slow process, which required 3 days ... This IL-1 induced activation of pro-MMP-9 was observed in intact skin but not in isolated dermal fibroblasts or keratinocytes ... IL-1 induced activation of pro-MMP-9 was inhibited by chymostatin, a chymotrypsinlike proteinase inhibitor
Hosseini et al., Invest Ophthalmol Vis Sci 2006 : JNK activity is necessary for the induction of MMP-3 and MMP-9 by TNFalpha, IL-1alpha , or IL-1beta in TM cells
Kundu et al., J Biol Chem 2006 (Helicobacter Infections) : In addition, increased secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta , and IL-6 induced pro-MMP-9 secretion and synthesis in AM1 or SS1 strain infected mice suggesting elicitation of pro-inflammatory cytokines by both cag- and cag+ genotype
Fujisaki et al., Life Sci 2007 : In the presence of IL-1alpha , expression of CAII, cathepsin K, and MMP-9 was markedly increased in cells cultured with RANKL or M-CSF+RANKL, whereas expression was difficult to detect in cells cultured with IL-1alpha alone and M-CSF ... These results indicate that the expression of CAII, cathepsin K, and MMP-9 in RAW264.7 cells is not induced by M-CSF, but by RANKL in the presence of IL-1alpha
Guay et al., Reproduction 2007 (Endometriosis) : In these cells, IL1R2 expression was markedly reduced, compared with non transfected cells or cells transfected with the empty vector, and there was a significant increase in the basal and the IL1-beta (IL1B) induced levels of matrix metalloproteinase (MMP)-2 and MMP-9 secretion
Wilusz et al., J Orthop Res 2008 : We used an in vitro model system to examine the hypotheses that acute exposure to IL-1 inhibits meniscal repair, and that an IL-1 mediated increase in matrix metalloproteinase ( MMP ) activity is associated with the inhibition of repair
Yan et al., Liver Int 2008 (Disease Models, Animal...) : In response to IL-1 , massive MMP-9 was produced by the 3D culture concomitantly with degradation of type-IV collagen
Rae et al., Fertil Steril 2009 : The IL-1alpha stimulated MMP9 mRNA production was suppressed by cortisol but not P. Cortisol but not P also dose-dependently suppressed IL-1alpha stimulated MMP9 gelatinase activity and this effect was blocked by the glucocorticoid receptor antagonist RU486 ... In human OSE cells, stimulation of MMP9 gene expression and proteolytic activity by IL-1alpha is suppressed by anti-inflammatory cortisol through a glucocorticoid receptor mediated mechanism
McNulty et al., Clin Orthop Relat Res 2009 : In the presence of IL-1 , the broad-spectrum MMP inhibitor GM 6001 decreased the MMP activity in the media, increased the shear strength of repair, and enhanced tissue repair in the interface
Zhang et al., J Surg Res 2009 : The AP-1 siRNA also significantly inhibited PDGF/IL-1 induced MMP-2 and MMP-9 gelatinolytic activity in VSMCs
Maqbool et al., Atherosclerosis 2009 : Using a standardized, controlled protocol we investigated the effects of phorbol ester ( TPA ) and a physiological stimulus ( PDGF+IL-1 ) on MMP-9 expression in cultured SV-SMC from 15 CC, 15 CT and 3 TT patients, and on PDGF+IL-1 induced SV-SMC invasion ( Boyden chamber with Matrigel barrier )
Vosgerau et al., Biochem Pharmacol 2010 : Treatment of VSMCs with HKa reduced in a concentration dependent manner IL-1alpha induced release of MMP-9 and MMP-2, associated with decreased MMP enzymatic activity levels in conditioned media, as demonstrated by gelatin zymography and fluorescein labeled gelatin substrate assay, respectively
McNulty et al., Osteoarthritis Cartilage 2010 (Knee Injuries) : IL-1 increased MMP activity, S-GAG release, and NO production, while decreasing the shear strength and tissue repair in the interface
Lemke et al., Cell Tissue Res 2010 (Arthritis) : Significant IL-1 effects were a decrease in biosynthetic activity, an increase in GAG release and in the expression/abundance of MMP-2, MMP-3 and ADAMTS4
Litherland et al., J Biol Chem 2010 : However, MMP1 and MMP13 induction by IL-1 + OSM was inhibited only by aPKC silencing, suggesting that only atypical isoforms play a significant role in complex inflammatory milieus
Wang et al., J Biol Chem 2010 : We examined adhesion restricted signaling pathways that enable IL-1 induced MMP release in human gingival and murine fibroblasts
García-Arnandis et al., Arthritis Res Ther 2010 (MAP Kinase Signaling System...) : In OA synoviocytes, HMGB1 alone at concentrations of 15 or 25 ng/ml did not affect the production of IL-6, IL-8, CCL2, CCL20, MMP-1 or MMP-3, but in the presence of IL-1ß , a significant potentiation of protein and mRNA expression, as well as MMP activity was observed
Zhang et al., Mol Hum Reprod 2011 : Pretreatment of EcSCs with PDTC attenuated IL-1ß induced expressions of CD44s, MMP-2 , MMP-9 and survivin at gene and protein levels
Pathak et al., J Immunol 2011 (Autoimmune Diseases...) : Increasing MMP-9 expression correlated with increasing IL-1ß concentration, suggesting that IL-1ß expression regulates MMP-9 expression
Zhang et al., Inflammation 2012 (Arthritis, Rheumatoid...) : IL-1ß or TNF-a increased expression of MMP-9 and MMP-2 in rheumatoid synoviocytes ; EGF stimulated expression of MMP-9 but not of MMP-2 ; genistein suppressed production of MMP-9 more than MMP-2 induced by IL-1ß or TNF-a ; rMMP-9, rMMP-2, or their inhibitors had no effect on the ( 3 ) H-TdR incorporation of synovial cells ... While pretreatment with PD098059 had no marked inhibitory effect on MMP-9 expression induced by TNF-a or IL-1ß , SP600125 decreased significantly the MMP-9 expression induced by TNF-a or IL-1ß
Toegel et al., Genes & nutrition 2012 : We further observed that the levels of IL1ß induced MMP-1, MMP-3 , MMP-7, and MMP-9 mRNA, but not TIMP mRNA levels, were down-regulated in chondrocytes in response to CSE
Akhtar et al., BMC complementary and alternative medicine 2011 (Osteoarthritis) : Effect of HLM on IL-1ß induced gene expression of iNOS, MMP-9 , MMP-13, ACAN and COL2A1 was verified by real time-PCR
Butoi et al., Biochim Biophys Acta 2011 : Silencing the p65 ( NF-kB subunit ) inhibited the IL-1ß and IL-6 and silencing c-jun inhibited the TNFa, CX3CR1 and MMP-9 induced by SMC-monocyte interaction
Pecchi et al., Osteoarthritis Cartilage 2012 : IL-1ß increased COX-2, mPGES-1, MMP-3 , MMP-13, RANKL expressions, decreased 15-PGDH expression, and increased PGE2, MMP-3 and MMP-13 release ... Accordingly, IL-1ß induced PGE2, MMP-3 and MMP-13 releases were inhibited by 86 % ( P < 0.001 ), 58 % ( P < 0.001 ) and 38 % ( P < 0.01 ) respectively ... Interestingly, 7 days of CS treatment significantly counteracted IL-1ß induced expression of COX-2 ( -62 %, P < 0.001 ), mPGES-1 ( -63 %, P < 0.001 ), MMP-3 ( -39 %, P=0.08 ), MMP-13 ( -60 %, P < 0.001 ) and RANKL ( -84 %, P < 0.001 )
Ma et al., Arthritis Rheum 2012 (Wnt Signaling Pathway) : The aim of this study was to investigate the role of Wnt/ß-catenin signaling in interleukin-1ß (IL-1ß) induced MMP expression in human chondrocytes ... Wnt/ß-catenin signaling in human chondrocytes had an unexpected anticatabolic role by counteracting NF-?B mediated MMP expression induced by IL-1ß in a negative feedback loop
Kular et al., Journal of neuroinflammation 2012 (Disease Models, Animal...) : In vitro, results based on cultured DRG neurons showed that siRNA mediated inhibition of NOV enhanced IL-1ß- and TNF-a induced MMP-2, MMP-9 and CCL2 expression whereas NOV addition inhibited TNF-a induced MMP-9 expression through ß1 integrin engagement
Kapral et al., Int J Colorectal Dis 2012 (Colonic Neoplasms...) : Stimulation of cells with IL-1ß only resulted in an overexpression of MMP and their TIMP mRNAs ... Proinflammatory cytokine IL-1ß upregulates MMP and TIMP mRNAs expression in colon cancer epithelial cells Caco-2
Berta et al., Molecular pain 2012 : Acute morphine induces opioid receptors- and MMP-9 dependent up-regulation of GFAP expression and IL-1ß activation in SGCs of DRGs. MMP-9 could mask and shorten morphine analgesia via peripheral neuron-glial interactions
Reynolds et al., Br J Pharmacol 2012 (Arthritis, Experimental...) : A role for IL-1ß in perpetuating contractile dysfunction and increasing aortic MMP-9 was excluded
Zhou et al., Invest Ophthalmol Vis Sci 2012 (Disease Models, Animal) : IL-1ß induced MMP expression and activation as well as collagen degradation were also blocked by the p38 MAPK inhibitor SB203580
Qin et al., J Endocrinol 2012 : Melatonin inhibits IL1ß induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-?B activation ... MMP9 expression was increased with IL1ß induction in HUVECs
Fioravanti et al., J Pharmacol Sci 2012 (Osteoarthritis) : The presence of IL-1ß led to a significant increase in PGE ( 2 ), MMP-3 , and NO production, as well as a significant increase in gene expression of COX-2 and iNOS
Bougault et al., Arthritis Rheum 2012 (Disease Models, Animal...) : LPS, IL-1a , and TNFa dose-dependently increased MMP-3, MMP-9 , and MMP-13 activity in cultured chondrocytes and in NLRP3 ( -/- ) chondrocytes, and this effect was not changed by inhibiting caspase 1 or IL-1ß
Sinfield et al., Biochem Biophys Res Commun 2013 : Selective p38a siRNA gene silencing reduced IL-1a induced IL-6 and MMP-3 mRNA expression and protein secretion, without affecting IL-1a induced IL-1ß and MMP-9 mRNA expression
Petrella et al., Cancer medicine 2012 : Specifically, IL-1ß induced the expression of MMP-1, MMP-3 , MMP-10, and MT1-MMP in a mechanism dependent on IL-1ß activation of the transcription factor CCAAT enhancer binding protein ß ( CEBPß )
Lim et al., Mol Hum Reprod 2013 (Inflammation...) : In myometrial cells, all treatments attenuated IL-1ß induced COX-2 expression, release of PGE2 and PGF2a and expression and activity of MMP-9
Tseng et al., PloS one 2013 : However, the detailed mechanisms of IL-1ß induced MMP-9 expression in Statens Seruminstitut Rabbit Corneal Cells ( SIRCs ) are largely unclear ... Here, we demonstrated that in SIRCs, IL-1ß induced MMP-9 promoter activity and mRNA expression associated with an increase in the secretion of pro-MMP-9 ... IL-1ß induced pro-MMP-9 expression and MMP-9 mRNA levels were attenuated by pretreatment with the inhibitor of MEK1/2 ( U0126 ), JNK1/2 ( SP600125 ), NF-?B ( Bay11-7082 ), or AP-1 ( Tanshinone IIA ) and transfection with siRNA of p42 or JNK2 ... These results suggested that NF-?B and AP-1 activated by JNK1/2 and p42/p44 MAPK cascade are involved in IL-1ß induced MMP-9 expression in SIRCs
Wei et al., Spine (Phila Pa 1976) 2013 : ERK inhibition reversed the changes of protein expression of MMP-3, MMP-13 , TIMP-1, aggrecan and collagen II induced by IL-1
Wall et al., Oxidative medicine and cellular longevity 2013 : Luteolin and kaempferol significantly reduced LPS induced secretion of proinflammatory cytokines ( IL-6 and IL-8 ) and prostaglandins ( PGE2 and PGF2 a ) in fetal membranes, IL-1ß induced COX-2 gene expression and prostaglandin production in myometrium, and IL-1ß induced MMP-9 activity in amnion and myometrial cells
Rawdanowicz et al., J Clin Endocrinol Metab 1994 : Both interleukin-1 alpha and tumor necrosis factor-alpha stimulated the secretion of MMP-1, MMP-3 , and MMP-9, but not MMP-2, from the cells in a concentration dependent manner ... Both interleukin-1 alpha and tumor necrosis factor-alpha stimulated the secretion of MMP-1, MMP-3, and MMP-9 , but not MMP-2, from the cells in a concentration dependent manner
Samples et al., Invest Ophthalmol Vis Sci 1993 : When added together, dexamethasone antagonizes the interleukin-1 alpha induced increase of stromelysin, gelatinase B , and TIMP1 in a dose dependent manner
Watanabe et al., J Cell Sci 1993 : 12-o-tetradecanoyl 13-phorbol acetate ( TPA ) differentiated them to macrophage-like cells with induction of MMP-9, and tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) stimulated the production of MMP-9 by TPA treated cells
Mohtai et al., J Clin Invest 1993 : IL-1 alpha treatment of normal human cartilage explants or isolated chondrocytes induced increased levels of gelatinase B and increased mRNA for tissue collagenase and stromelysin-1
Tamura et al., Endocrinology 1996 (Arthritis...) : Gelatin zymography of the RAC culture medium revealed that IL-1 increased the production of matrix metalloproteinase-2 (MMP-2) and MMP-9
Sato et al., FEBS Lett 1996 : The suppressive effect of IL-1alpha on the TNFalpha induced proMMP-9 production is a new biological effect of IL-1 on MMP production
Kusano et al., Endocrinology 1998 (Bone Resorption) : In mouse calvarial cultures, IL-1 markedly enhanced the messenger RNA ( mRNA ) expression of MMP-13 ( collagenase 3 ), MMP-2 ( gelatinase A ), MMP-9 ( gelatinase B ), and MMP-3 ( stromelysin 1 ), which associated with increases in bone matrix degradation ... In mouse osteoblastic cells, the expression ofMMP-2, MMP-3 , and MMP-13 mRNAs could be detected, and they were markedly enhanced by IL-1alpha on days 2 and 5
Sasaki et al., J Biochem 1998 : Gelatin and casein zymography revealed that IL-1 stimulated the production of not only MMP-9 but also MMP-3 ... IL-1 sequentially stimulated mRNA expression of iNOS, membrane type 1-MMP , MMP-9 and -3, and bFGF, in that order
Alexander et al., Curr Eye Res 1998 : A phorbol mitogen ( TPA ), and TNF alpha and beta, interleukin-1 alpha and PDGF BB stimulate gelatinase B , stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression ; TIMP-2 levels are reduced by TNF but not affected by the other treatments
Esteve et al., Biochim Biophys Acta 1998 : We showed that IL-1 and TNFalpha both induced gene expression and protein secretion of Gel B in both cell lines, as revealed by RT-PCR and gelatin zymography, respectively ... Taken together, these data suggest that IL-1 , TNFalpha and TGFbeta2 tightly regulate Gel B secretion in glioma cells, an enzyme which is believed to play an important role in the local invasion of brain tissue by tumor cells
Andersen et al., Anticancer Res 1998 (Bone Neoplasms...) : The CAPL protein expressed in cell-cultures appear to block the MMP induction by bFGF and Il-1 alpha