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AIM2 — IL1A
Text-mined interactions from Literome
Coll et al., PloS one 2011
(Inflammation) :
In murine bone marrow derived macrophages, CRID3 inhibited
IL-1ß secretion and caspase 1 processing in
response to stimulation of NLRP3 and
AIM2 but not NLRC4
Saiga et al., Int Immunol 2012
(Tuberculosis, Pulmonary) :
Genomic DNA extracted from M. tuberculosis ( Mtb DNA ) induced caspase-1 activation and
IL-1ß/IL-18 secretion in an
AIM2 dependent manner
Koo et al., PloS one 2012
(Scrub Typhus) :
Furthermore, Orientia stimulated secretion of IL-1ß and activation of caspase-1 are ASC- and caspase-1- dependent since
IL-1ß production was
impaired in Asc- and caspase-1-deficient macrophages but not in Nlrp3-, Nlrc4- and
Aim2-deficient macrophages
Chen et al., EMBO Mol Med 2012
(Inflammation...) :
In tumour cells,
AIM2 and RIG-I are
required for
IL-1ß induction by EBV genomic DNA and EBV encoded small RNAs, respectively, while NLRP3 responds to extracellular ATP and reactive oxygen species
Dotson et al., J Biol Chem 2013
(Tularemia) :
An enhanced activation of caspase-1 and
IL-1ß observed in FTL_0325 mutant infected macrophages at 24 h post-infection was
independent of both
AIM2 and NLRP3