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HMOX1 — PRL

Text-mined interactions from Literome

Malaguarnera et al., Int J Mol Med 2002 (Neovascularization, Pathologic) : Both protein synthesis and mRNA analysis confirmed that HO-1 expression was induced by prolactin in cultured endothelial cells and occurred in a concentration dependent manner ... Incubation of human microvessel endothelial cells transduced with HO-1 in sense orientation resulted in enhancement of prolactin mediated increase in endothelial cell proliferation and angiogenesis, whereas inhibition of HO-1 by transduction of HO-1 in antisense orientation prevented prolactin increase in endothelial cell proliferation
Malaguarnera et al., J Cell Biochem 2004 : Prolactin increases HO-1 expression and induces VEGF production in human macrophages ... Furthermore, to determine whether PRL induced HO-1 activity was required for VEGF production by macrophages, the effect of PRL on the induction of VEGF was studied in the presence of an inducer stannic chloride ( SnCl ( 2 ) ) and of an inhibitor stannic mesoporphyrin ( SnMP ) of HO activity