Gene interactions and pathways from curated databases and text-mining

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EPO — GSK3B

Text-mined interactions from Literome

Wu et al., Apoptosis 2007 : The effects of EPO on GSK-3beta and caspase-3 activities were also blocked by LY294002
Nishihara et al., J Mol Cell Cardiol 2007 (Disease Models, Animal...) : To get an insight into the mechanism by which phospho-GSK-3beta protects the myocardium from ischemia/reperfusion injury, we examined the effects of IPC and EPO on interactions between GSK-3beta and subunits of the mitochondrial permeability transition pore ( mPTP ) in this study ... IPC+EPO significantly increased the levels of GSK-3beta and phospho-GSK-3beta that were co-immunoprecipitated with ANT to 145+/-8 % and 143+/-16 %, respectively, of baseline but did not induce phospho-GSK-3beta-VDAC binding ... A PKC inhibitor and a PI3 kinase inhibitor suppressed the IPC+EPO induced increase in the level of phospho-GSK-3beta-ANT complex
Ohori et al., Am J Physiol Heart Circ Physiol 2008 : However, EPO increased the level of Ser9-phospho-GSK-3beta colocalized with mitochondria by 50 % in a phosphatidylinositol 3-kinase dependent manner
Miki et al., Diabetes 2009 (Body Weight...) : However, neither phosphorylation of Akt and GSK-3beta nor infarct size limitation was induced by EPO in OLETF rats