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CD4 — MPO
Text-mined interactions from Literome
Ooi et al., Proc Natl Acad Sci U S A 2012
(Glomerulonephritis...) :
Transfer of an MPO ( 409-428 ) -specific
CD4 ( + ) T-cell clone to Rag1 ( -/- ) mice
induced focal necrotizing glomerulonephritis when glomerular MPO deposition was induced either by passive transfer of MPO-ANCA and LPS or by planting
MPO ( 409-428 ) conjugated to a murine antiglomerular basement membrane mAb
Gan et al., J Am Soc Nephrol 2012
(Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis...) :
Mast cell-deficient mice exhibited more antimyeloperoxidase
CD4+ T cells, enhanced dermal delayed-type hypersensitivity
responses to
myeloperoxidase , and more severe focal necrotizing GN
Gan et al., Cell Immunol 2013
(Glomerulonephritis) :
Therefore,
MPO-ANCA can
induce glomerulonephritis through both direct humoral mechanisms ( recruitment of neutrophils and deposition of MPO ) and indirectly by initiating MPO deposition in glomeruli, thereby directing effector
CD4 ( + ) T cell mediated injury