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MIF — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MIF → TNF (increases)
  Evidence: Furthermore, it has been shown that MIF not only acts on macrophages, but it is also produced by these cells in response to endotoxins, exotoxins and cytokines such as TNF and interferon- [4] .

Text-mined interactions from Literome

Hines et al., Vet Microbiol 1999 : MIF-A3 does induce secretion of IL-6, but does not induce secretion of TNFalpha , IL-1beta, and GM-CSF
Leech et al., Arthritis Rheum 1999 (Arthritis, Rheumatoid) : Synoviocyte MIF was not increased by IL-1beta, TNFalpha , or IFNgamma
Nishihira et al., Semin Thromb Hemost 1999 : Induction of T-kininogen and tumor necrosis factor-alpha by macrophage migration inhibitory factor in vivo
Benigni et al., J Clin Invest 2000 : The catabolic effect of TNF-alpha on myotubes was mediated by MIF , which served as an autocrine stimulus for F2, 6BP production
Lai et al., J Pathol 2003 (Disease Models, Animal...) : MIF induced significant MIF and tumour necrosis factor (TNF)-alpha synthesis in cultured endothelial cells and the effect was blocked by neutralizing anti-MIF antibody ... A similar blocking effect was observed when MIF stimulated endothelial cells were pretreated with neutralizing anti-TNF-alpha antibody or glucocorticoid, supporting the notion that MIF induced TNF-alpha production via an amplifying pro-inflammatory loop
Kariya et al., Clin Diagn Lab Immunol 2003 (Otitis Media with Effusion) : MIF was detected in 97.9 % of the MEEs from adults, while endotoxin, IL-1beta, TNF-alpha , and RANTES were detected in 96.8, 12.6, 5.3, and 43.9 %, respectively
Razzaque et al., Invest Ophthalmol Vis Sci 2004 (Conjunctivitis...) : In addition, the effects of interleukin (IL)-1, tumor necrosis factor (TNF)-alpha , and transforming growth factor (TGF)-beta1 on the induction of MIF by conjunctival fibroblasts were studied by quantitative real-time PCR
Burger-Kentischer et al., Atherosclerosis 2006 (Aortitis...) : Importantly, the local aortic expression of ICAM-1, MMP-2, TNF , IL-12, and CD40L was reduced by MIF blockade, as were the levels of the phospho-c-Jun and C/EBPbeta transcription factors
Cao et al., Hum Reprod 2006 : Results from enzyme linked immunosorbent assay ( ELISA ) demonstrated a significant dose- and time dependent increase in MIF secretion by human endometrial cells in response to tumour necrosis factor-alpha (TNF-alpha) ( 0.1-100 ng/ml ) ... The expression of a dominant negative NF-kappaB inhibitor ( IkappaB ) significantly decreased the TNF-alpha induced MIF promoter activity as analysed by transient cell transfection
Roger et al., Eur J Immunol 2005 : Recombinant MIF counter regulated in a dose dependent fashion dexamethasone inhibition of TNF and IL-8 production by RAW 264.7 macrophages and U-937 promonocytes stimulated with lipopolysaccharides (LPS) or with LPS plus phorbol 12-myristate 13-acetate
Lin et al., Shock 2005 (Heart Diseases...) : Exogenous MIF , instilled into the lungs, increased alveolar keratinocyte derived chemokine ( KC ), Macrophage inflammatory protein-2 (MIP2), and tumor necrosis factor alpha (TNFalpha) at 3 h, and plasma KC and MIP2 at 6 h postinstillation
Daryadel et al., J Biol Chem 2006 (Inflammation) : Apoptotic neutrophils release macrophage migration inhibitory factor upon stimulation with tumor necrosis factor-alpha ... Moreover, TNF-alpha mediated MIF release was blocked by glyburide and propenicide, both inhibitors of ATP binding cassette-type transporters, suggesting that this transporter system is activated during neutrophil apoptosis
Ohkawara et al., Immunol Lett 2006 (Colitis) : Lack of MIF suppressed the up-regulation of TNF-alpha and IFN-gamma as Th1 derived cytokines, and increased the level of IL-4 as Th2 derived cytokine in the colon tissues
Houdeau et al., Gastroenterology 2007 (Colitis...) : Progesterone enhanced TNBS induced MIF ( P < .001 ) and TNF-alpha ( P < .01 ) production, while EB decreased MIF ( P < .01 ) and IL-beta levels ( P < .01 )
Son et al., Antioxid Redox Signal 2009 : Furthermore, anti-TRX antibody inhibited MIF mediated enhancement of TNF-alpha production from macrophage RAW264.7 cells
Kim et al., Korean J Intern Med 2010 (Arthritis, Rheumatoid) : MIF was also induced by interferon-?, CD40 ligand, interleukin-15, interleukin-1ß, tumor necrosis factor-a , and transforming growth factor-ß
Cavalcanti et al., PloS one 2011 (Ileitis...) : Lack of MIF caused a reduction of TNF-a , IL-12, IFN-? and IL-23 and an increased expression of IL-22 in ileal mucosa
Liu et al., Cytokine 2012 (Ischemia...) : MIF released by isolated cold preserved livers, induced TNF-a and IL-1ß production by cultured peritoneal macrophages
Herriott et al., J Immunol 1993 : MIF and IFN-gamma synergize with lipid A to mediate migration inhibition but only IFN-gamma induces production of TNF-alpha and nitric oxide
Bernhagen et al., Biochemistry 1994 : MIF induced the secretion of tumor necrosis factor-alpha and stimulated nitric oxide production by macrophages primed with interferon-gamma
Calandra et al., J Exp Med 1994 : In RAW 264.7 macrophages, MIF secretion also was induced by tumor necrosis factor alpha (TNF-alpha) and IFN-gamma, but not by interleukins 1 beta or 6
Donnelly et al., Nat Med 1997 (Respiratory Distress Syndrome, Newborn) : We show in alveolar cells from patients with ARDS that MIF augments pro-inflammatory cytokine secretion ( TNF alpha and IL-8 ), anti-MIF significantly attenuates TNF alpha and IL-8 secretion and MIF overrides, in a concentration related fashion, the anti-inflammatory effects of glucocorticoids
Hirokawa et al., Biochem Biophys Res Commun 1997 : The results showed that MIF content was 1.6 +/- 0.48 ng/ml ( mean +/- SD ) after 24 hr culture, and the content was increased up to 9.7 +/- 2.8 ng/ml by stimulation with TNF-alpha ( 50 nM )
Hirokawa et al., J Biochem 1998 : Tumor necrosis factor-alpha regulates the gene expression of macrophage migration inhibitory factor through tyrosine kinase dependent pathway in 3T3-L1 adipocytes ... Since adipocytes are regarded as a potential source of various biologically active substances, we examined in more detail the effect of TNF-alpha on MIF expression in 3T3-L1 adipocytes in the present study ... This observation indicates that TNF-alpha stimulates MIF secretion from the constitutively expressed intracellular pool of 3T3-L1 adipocytes and promotes de novo synthesis of MIF ... The results suggest the possibility that upregulation of MIF mRNA expression by TNF-alpha is mediated by a tyrosine kinase dependent pathway