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CCL3 — TNF
Text-mined interactions from Literome
Bliss et al., J Immunol 1999
(Toxoplasmosis) :
These results establish that T. gondii possesses the ability of driving neutrophil proinflammatory cytokine production, and they suggest that parasite induced
MIP-1 alpha and MIP-1 beta partly
results from autocrine stimulation through
TNF-alpha
Netea et al., Eur J Immunol 2000
(Chlamydia Infections) :
In contrast, synthesis of MCP-1 and
MIP-1alpha was
dependent on endogenous
TNF , but not IL-1
Brice et al., J Acquir Immune Defic Syndr 2000
:
Results of these studies show that the anti-viral resistance induced by activation of CD4+ T cells with anti-CD3 + anti-CD28 is primarily conferred by the synthesis of tumor necrosis factor-alpha (TNF-alpha), and highlight a unique regulatory
role for
TNF-alpha in regulating synthesis of
MIP-1alpha , MIP-1beta, and regulated-on-activation normal T-expressed and secreted cells, which contributes to this state of antiviral resistance to R5-tropic strains of HIV/SIV
Matejuk et al., J Neurosci Res 2002
(Encephalomyelitis, Autoimmune, Experimental) :
Of note, we present evidence that
TNF-alpha may be
involved in regulating RANTES and
MIP-1alpha , and that IL-4 may be involved in regulating MCP-1
Oltmanns et al., Exp Lung Res 2003
(Pneumonia...) :
Stimulation with
TNF-alpha or IL-1beta
increased the MIP-1alpha and GM-CSF release from AM of normal controls and patients with pneumonia and interstitial lung disease : however, no further enhancement of
MIP-1alpha and GM-CSF production was observed in AM from sarcoidosis patients
Ramos et al., J Leukoc Biol 2005
(Autoimmune Diseases...) :
In summary, we have demonstrated that neutrophil migration observed in this model of immune inflammation is mediated by
MIP-1alpha [ CCL3 ], which via CCR1,
induces the sequential release of
TNF-alpha and LTB ( 4 )
Nath et al., Cancer Immunol Immunother 2006
(Adenocarcinoma...) :
Interleukin-1 (IL-1) and tumor necrosis factor
(TNF) alpha release by the PBM was markedly
stimulated by
MIP1alpha in CaBr patients, but only marginally so in healthy women
Ramos et al., Eur J Immunol 2006
:
We have recently shown that antigen induced neutrophil migration into the peritoneum of immunized mice is mediated by macrophage-inflammatory protein
(MIP)-1alpha which interacts with CCR1 and
induces the sequential release of
TNF-alpha and leukotriene B ( 4 ) ( LTB ( 4 ) )
Shiau et al., J Immunol 2007
(Arthritis, Rheumatoid) :
AdProTDeltaNLS treatment abolished the up-regulation of the
MIP-1alpha promoter activity
induced by
TNF-alpha in synovial fibroblasts
Fan et al., Immunology 2007
:
LPS induced production of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), IL-10 and interferon-gamma-inducible protein-10 (IP-10); SA induced
TNF-alpha , and IL-1beta production ; and GBS
induced TNF-alpha, IL-6, IL-1beta,
macrophage inflammatory protein-1alpha ( MIP-1alpha ) and keratinocyte chemoattract ( KC ) production were all decreased ( P < 0.05 ) in Galpha ( i2 ) ( -/- ) or Galpha ( i1/3 ) ( -/- ) mice compared with WT mice
Narni-Mancinelli et al., J Exp Med 2007
(Listeriosis) :
CCL3 induces a rapid
TNF-alpha secretion by innate inflammatory mononuclear phagocytic cells ( MPCs ), which further promotes the production of radical oxygen intermediates ( ROIs ) by both MPCs and neutrophils
Guerrero-Plata et al., J Immunol 2009
(Acute Disease...) :
In vitro infection of lung DC indicated that in pDC, production of IFN-alpha,
TNF-alpha , and CCL5 was
induced only by hMPV, whereas
CCL3 and CCL4 were induced by both viruses
Sethu et al., PloS one 2010
(Disease Models, Animal...) :
Similarly
TNFalpha caused an increase in the serum levels of IL-6,
MIP-1alpha and MIP-1beta : this increase in cytokine/chemokine levels was inhibited in mice where PLD1 had been silenced
Hachicha et al., J Exp Med 1995
(Gout...) :
IL-8 production induced by TNF-alpha and GM-CSF was synergistically enhanced in the presence of MSU or CPPD, whereas
MIP-1 alpha secretion
induced by
TNF was completely inhibited in the presence of either MSU or CPPD
Smith et al., J Leukoc Biol 1995
(Pulmonary Fibrosis) :
Furthermore, our results indicate that
MIP-1 alpha expression is
mediated by alveolar macrophage derived
tumor necrosis factor , identifying an important cytokine pathway in the initiation of pulmonary fibrosis
McManus et al., J Immunol 1998
:
In
response to LPS,
TNF-alpha , or IL-1 beta, both
MIP-1 alpha and MIP-1 beta were induced at the mRNA and protein levels in a dose- and time dependent manner
Dürig et al., Blood 1998
(Neoplasms) :
TNF-alpha induced
MIP-1alpha receptor upregulation in a time- and concentration dependent manner