Gene interactions and pathways from curated databases and text-mining

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CCL3 — TNF

Text-mined interactions from Literome

Bliss et al., J Immunol 1999 (Toxoplasmosis) : These results establish that T. gondii possesses the ability of driving neutrophil proinflammatory cytokine production, and they suggest that parasite induced MIP-1 alpha and MIP-1 beta partly results from autocrine stimulation through TNF-alpha
Netea et al., Eur J Immunol 2000 (Chlamydia Infections) : In contrast, synthesis of MCP-1 and MIP-1alpha was dependent on endogenous TNF , but not IL-1
Brice et al., J Acquir Immune Defic Syndr 2000 : Results of these studies show that the anti-viral resistance induced by activation of CD4+ T cells with anti-CD3 + anti-CD28 is primarily conferred by the synthesis of tumor necrosis factor-alpha (TNF-alpha), and highlight a unique regulatory role for TNF-alpha in regulating synthesis of MIP-1alpha , MIP-1beta, and regulated-on-activation normal T-expressed and secreted cells, which contributes to this state of antiviral resistance to R5-tropic strains of HIV/SIV
Matejuk et al., J Neurosci Res 2002 (Encephalomyelitis, Autoimmune, Experimental) : Of note, we present evidence that TNF-alpha may be involved in regulating RANTES and MIP-1alpha , and that IL-4 may be involved in regulating MCP-1
Oltmanns et al., Exp Lung Res 2003 (Pneumonia...) : Stimulation with TNF-alpha or IL-1beta increased the MIP-1alpha and GM-CSF release from AM of normal controls and patients with pneumonia and interstitial lung disease : however, no further enhancement of MIP-1alpha and GM-CSF production was observed in AM from sarcoidosis patients
Ramos et al., J Leukoc Biol 2005 (Autoimmune Diseases...) : In summary, we have demonstrated that neutrophil migration observed in this model of immune inflammation is mediated by MIP-1alpha [ CCL3 ], which via CCR1, induces the sequential release of TNF-alpha and LTB ( 4 )
Nath et al., Cancer Immunol Immunother 2006 (Adenocarcinoma...) : Interleukin-1 (IL-1) and tumor necrosis factor (TNF) alpha release by the PBM was markedly stimulated by MIP1alpha in CaBr patients, but only marginally so in healthy women
Ramos et al., Eur J Immunol 2006 : We have recently shown that antigen induced neutrophil migration into the peritoneum of immunized mice is mediated by macrophage-inflammatory protein (MIP)-1alpha which interacts with CCR1 and induces the sequential release of TNF-alpha and leukotriene B ( 4 ) ( LTB ( 4 ) )
Shiau et al., J Immunol 2007 (Arthritis, Rheumatoid) : AdProTDeltaNLS treatment abolished the up-regulation of the MIP-1alpha promoter activity induced by TNF-alpha in synovial fibroblasts
Fan et al., Immunology 2007 : LPS induced production of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), IL-10 and interferon-gamma-inducible protein-10 (IP-10); SA induced TNF-alpha , and IL-1beta production ; and GBS induced TNF-alpha, IL-6, IL-1beta, macrophage inflammatory protein-1alpha ( MIP-1alpha ) and keratinocyte chemoattract ( KC ) production were all decreased ( P < 0.05 ) in Galpha ( i2 ) ( -/- ) or Galpha ( i1/3 ) ( -/- ) mice compared with WT mice
Narni-Mancinelli et al., J Exp Med 2007 (Listeriosis) : CCL3 induces a rapid TNF-alpha secretion by innate inflammatory mononuclear phagocytic cells ( MPCs ), which further promotes the production of radical oxygen intermediates ( ROIs ) by both MPCs and neutrophils
Guerrero-Plata et al., J Immunol 2009 (Acute Disease...) : In vitro infection of lung DC indicated that in pDC, production of IFN-alpha, TNF-alpha , and CCL5 was induced only by hMPV, whereas CCL3 and CCL4 were induced by both viruses
Sethu et al., PloS one 2010 (Disease Models, Animal...) : Similarly TNFalpha caused an increase in the serum levels of IL-6, MIP-1alpha and MIP-1beta : this increase in cytokine/chemokine levels was inhibited in mice where PLD1 had been silenced
Hachicha et al., J Exp Med 1995 (Gout...) : IL-8 production induced by TNF-alpha and GM-CSF was synergistically enhanced in the presence of MSU or CPPD, whereas MIP-1 alpha secretion induced by TNF was completely inhibited in the presence of either MSU or CPPD
Smith et al., J Leukoc Biol 1995 (Pulmonary Fibrosis) : Furthermore, our results indicate that MIP-1 alpha expression is mediated by alveolar macrophage derived tumor necrosis factor , identifying an important cytokine pathway in the initiation of pulmonary fibrosis
McManus et al., J Immunol 1998 : In response to LPS, TNF-alpha , or IL-1 beta, both MIP-1 alpha and MIP-1 beta were induced at the mRNA and protein levels in a dose- and time dependent manner
Dürig et al., Blood 1998 (Neoplasms) : TNF-alpha induced MIP-1alpha receptor upregulation in a time- and concentration dependent manner