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BLM — TNF
Text-mined interactions from Literome
Ortiz et al., Am J Physiol 1999
(Fibrosis...) :
Bleomycin (BLM) induces lung injury and fibrosis in the murine lung and
enhances tumor necrosis factor (TNF)-alpha and collagen mRNA expression in the murine lung
Xiao et al., Planta Med 2005
(Pulmonary Fibrosis) :
Moreover, IL also significantly inhibited the overexpression of
TNF-alpha and TGF-beta (1)
induced by
BLM ... These results indicated that IL possessed a significant inhibitory effect on BLM induced pulmonary fibrosis, probably due to its antioxidant and/or anti-inflammatory activities and inhibitory overexpressing
TNF-alpha and TGF-beta (1)
induced by
BLM
Ortiz et al., Proc Natl Acad Sci U S A 2007
(Fibrosis...) :
Therefore, MSCs protect lung tissue from
BLM induced injury by blocking
TNF-alpha and IL-1, two fundamental proinflammatory cytokines in lung
Aoki et al., Respiration 2009
(Acute Lung Injury...) :
PGZ also inhibited
BLM induced
TNF-alpha production in alveolar macrophages
Ortiz et al., Exp Lung Res 1998
(Pulmonary Fibrosis) :
These animals demonstrated an increased expression of
TNF , but not TGF-beta 1, mRNA in
response to
BLM and did not exhibit histologic evidence of lung injury following BLM exposure