Yu et al., Brain Res 2012
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Using echinomycin, a HIF-1 inhibitor, and HIF-1a siRNA, we demonstrated IGF-1 induced GLUT3 expression through HIF-1a in neuronal PC12 cells ... In conclusion, we showed that the expression of GLUT3 in response to IGF-1 was dependent on PI-3-kinase and mTOR activity, and required the transcription factor HIF-1a Thamotharan et al., Am J Physiol Endocrinol Metab 2013
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Thus, in N2A neuroblasts, phosphorylated HIF-1a and Creb mediated the hypoxia induced increase in glut3 transcription