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PRKAA2 — SETD2

Text-mined interactions from Literome

Lee et al., J Biol Chem 2003 (Prostatic Neoplasms) : In the present study, we considered a role of AMPK in the adaptive response to hypoxia by examining whether AMPK is involved in the regulation of hypoxia-inducible factor-1 (HIF-1) , a heterodimeric transcription factor that is critical for hypoxic induction of physiologically important genes ... Under these conditions, blockade of AMPK activity by a pharmacological or molecular approach significantly attenuated hypoxia induced responses such as HIF-1 target gene expression, secretion of vascular endothelial growth factor, glucose uptake, and HIF-1 dependent reporter gene expression, indicating that AMPK is critical for the HIF-1 transcriptional activity and its target gene expression ... Its functional requirement for HIF-1 activity was also demonstrated in several different cancer cell lines, but AMPK activation alone was not sufficient to stimulate the HIF-1 transcriptional activity
Emerling et al., FEBS Lett 2007 : Our results show that AMPK is not required for the hypoxic activation of HIF-1 ... Interestingly, the AMPK inhibitor, Compound C, inhibits the hypoxic activation of HIF-1 independent of AMPK
Bohensky et al., Pediatr Nephrol 2010 : Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression ... In addition, we showed that thapsigargin treatment activated AMPK and autophagy in a HIF-1 dependent manner ... Based on these findings, it is concluded that because of the micro-environmental changes experienced by the chondrocyte, autophagy is activated by AMPK in a HIF-1 dependent manner