Viau et al., J Clin Invest 2010
(Disease Progression...) :
EGFR inhibition prevented Lcn2 upregulation and lesion development in mice expressing a dominant negative EGFR isoform, and hypoxia-inducible factor 1a (Hif-1a) was crucially required for EGFR induced Lcn2 overexpression
Fernández-Martínez et al., Biochim Biophys Acta 2013
:
Thus, EGFR transactivation by intracellular PGE2 activated EP receptors results in the sequential activation of RARß and HIF-1a leading to increased production of VEGF-A and it may be a target for the therapeutic modulation of HIF-1a/VEGF-A