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ITGB3 — MMP2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MMP2 → Complex of ITGAV-ITGB3 (increases, ITGAV/ITGB3 Activity)
  Evidence: In addition, avb3 has been shown to bind MMP-2, in an RGD-independent way, thereby localizing MMP-2-mediated matrix degradation to the endothelial cell surface (28, 58). avb3 is nearly undetectable on quiescent endothelium, but is highly upregulated during cytokine or tumor-induced angiogenesis. In activated endothelium avb3 suppresses the activity of both p53 and the p53-inducible cell-cycle inhibitor p21WAF1/CIP1, while increasing the Bcl2:Bax ratio, resulting in an anti-apoptotic effect (226)...

Text-mined interactions from Literome

Banerji et al., J Environ Pathol Toxicol Oncol 2005 (Melanoma) : Among the MMPs, the 72 kDa type IV collagenase MMP-2 ( gelatinase A ) is activated in a membrane associated manner by an activation complex composed of membrane type 1 matrix metalloproteinase ( MT1-MMP ), tissue inhibitor of matrixmetalloproteinase-2 ( TIMP-2 ), and pro-MMP-2 in the presence of alphavbeta3 integrin receptor
Borrirukwanit et al., Matrix Biol 2007 (Breast Neoplasms) : The type I collagen induction of MT1-MMP mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells
Raffetto et al., J Surg Res 2010 (Varicose Veins) : MMP-2 induced VSM relaxation may not involve RGD generation or activation of alpha(v)beta(3) integrin receptor
Wu et al., Journal of thrombosis and haemostasis : JTH 2010 : Moreover, HKa completely blocked the association between pro-MMP-2 and alphavbeta3 integrin, and its inhibition of MMP-2 activation was dependent on the presence of alphavbeta3 integrin