◀ Back to MAPK15
IL17A — MAPK15
Text-mined interactions from Literome
Shimada et al., J Immunol 2002
:
Furthermore, IL-17, IL-1beta, and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs, and specific
MAPK inhibitors ( SB203580, PD98059, and U0216 ) significantly
reduced IL-17- , IL-1beta-, or TNF-alpha induced IL-6 secretion, indicating the role of MAPKs in the induction of IL-6
Hsieh et al., Cytokine 2002
(MAP Kinase Signaling System) :
Further,
IL-17 induced the phosphorylation of src kinase and
mitogen activated protein ( MAP ) kinase
Bamba et al., J Gastroenterol 2003
:
A c-Jun/activating protein-1 (AP-1) inhibitor, curcumin, reduced the
IL-17- , IL-1beta-, and TNF-alpha induced MMP-3 mRNA expression, and
mitogen activated protein ( MAP ) kinase inhibitors ( U0126, PD098059, and SB203580 ) also
blocked MMP-3 secretion
Wuyts et al., J Heart Lung Transplant 2005
:
Western blotting clearly demonstrated that p38
MAPK , JNK and p42/p44 ERK were
activated by
IL-17 in HASMC ... We found that
IL-17 induces activation of
p38MAPK , JNK and p42/p44ERK in HASMC
Ning et al., Am J Physiol Lung Cell Mol Physiol 2005
(MAP Kinase Signaling System) :
CO exposure selectively attenuated
IL-17 induced ERK1/ERK2
MAPK activation without significantly affecting either JNK or p38 MAPK activation
Kanda et al., J Allergy Clin Immunol 2005
:
IL-17 alone or synergistically with TNF-alpha
induced dual phosphorylation of p38
MAPK and ERK
Rahman et al., J Immunol 2006
(Asthma...) :
In addition,
IL-17A mediated rapid phosphorylation of
MAPK ( p38, JNK, and p42/44 ERK ) and STAT-3 but not STAT-6 or STAT-5 in ASM cells
Zhou et al., Cytokine 2007
(MAP Kinase Signaling System...) :
IL-17A significantly
induced activation of all three
MAPK ( ERK, p38 and JNK ) and downstream transcription factors AP-1 and p65 NFkappaB
Patel et al., J Biol Chem 2007
:
IL-17 stimulated p38
MAPK and ERK1/2 activation, and SB203580 and PD98059 blunted IL-17 mediated NF-kappaB and C/EBP activation and CRP transcription
Cortez et al., Am J Physiol Heart Circ Physiol 2007
:
IL-17 induced p38
MAPK and ERK1/2 activation, and inhibition by SB-203580 and PD-98059 blunted IL-17 mediated transcription factor activation and MMP-1 expression
Paradowska et al., Arch Immunol Ther Exp (Warsz) 2007
(Arthritis, Rheumatoid) :
IL-17 binding to an IL-17 receptor expressed on epithelial, endothelial, and fibroblastic stromal cells
triggers the activation of transcription factor NF-kappaB and
mitogen activated protein kinase ( p-38 ), which in turn results in the secretion of IL-1, TNF-alpha, IL-6, IL-8, or prostaglandin E2
Cheung et al., J Immunol 2008
(Inflammation) :
Further investigations showed that
IL-17A , IL-17F, and IL-23 differentially
activated the ERK, p38
MAPK , and NF-kappaB pathways
Brereton et al., J Immunol 2009
(Autoimmune Diseases) :
Inhibition of ERK
MAPK suppresses IL-23- and IL-1-driven
IL-17 production and attenuates autoimmune disease
Hosokawa et al., Cell Physiol Biochem 2009
:
EGCG and ECG prevented
IL-17A induced phosphorylation of p38
MAPK and ERK in HGFs
Iyoda et al., American journal of physiology. Renal physiology 2010
:
Additionally, we observed that
IL-17A and IL-17F
induced MAPK ( p38 MAPK, ERK1/2, and JNK ) activation and that pharmacological inhibitors of p38 MAPK ( SB203580 ) and ERK1/2 ( U0126 ), but not JNK ( SP600125 ), blocked the IL-17A/IL-17F mediated MCP-1 and MIP-2 release
Gislette et al., TheScientificWorldJournal 2010
(Neoplasms...) :
IL-17 could
activate Src/PI3K,
MAPK , Stat3, and PKC, resulting in carcinogenesis
Kim et al., Naunyn Schmiedebergs Arch Pharmacol 2011
:
The
IL-17 stimulated ERK 1/2, p38, and JNK
MAPK activities and GSPE decreased IL-17 stimulated ERK 1/2, p38, and JNK MAPK activities
Noubade et al., Blood 2011
(Chronic Disease...) :
Activation of p38
MAPK in CD4 T cells
controls IL-17 production and autoimmune encephalomyelitis
Valente et al., Cell Signal 2012
(Fibrosis...) :
IL-17A mediated p38
MAPK and ERK1/2 activation is inhibited by MKP-1 overexpression, but prolonged by MKP-1 knockdown
Chen et al., Molecular vision 2011
:
Inhibition of
p38MAPK , phosphoinositide 3-kinase (PI3K)-Akt and nuclear factor-kappaB ( NF-?B ), with the inhibitors SB203580, LY294002 and pyrrolydine dithiocarbamate ( PDTC ) respectively,
reduced IL-17 ( 100 ng/ml ) mediated production of CXCL8, CCL2, and IL-6 in a concentration dependent manner
Zhang et al., World J Gastroenterol 2012
(Inflammation...) :
IL-17A induced rapid phosphorylation of p38
MAPK and ERK1/2 after 5 min exposure, and showed the strongest levels of phosphorylation of p38 MAPK and ERK1/2 at 15 min in IL-17A treated HSCs. IL-6 mRNA expression induced by IL-17A ( 100 ng/mL ) for 3 h exposure was inhibited by preincubation with specific inhibitors of p38 MAPK ( SB-203580 ) and ERK1/2 ( PD-98059 ) compared to groups without inhibitors preincubation ( 1.67 ± 0.24, 2.01 ± 0.10 vs 4.08 ± 0.59, P < 0.01 )