Wang et al., Mol Immunol 2008
:
It has been shown that the protein kinase I kappaB kinase alpha (IKK alpha) is critically involved in IRF7 activation and IFN-alpha production in Toll-like receptor 7/9 ( TLR7/9 ) signaling cascades
Liang et al., Cell Res 2011
(Sarcoma, Kaposi) :
Importantly, expression of miR-K12-11 attenuated IFN signaling by decreasing IKK? mediated IRF3/IRF7 phosphorylation and by inhibiting the activation of IKK? dependent IFN stimulating genes ( ISGs ), allowing miR-K12-11 suppression of antiviral immunity