Gene interactions and pathways from curated databases and text-mining

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CTSD — IGF2R

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Dabrosin et al., Breast Cancer Res Treat 2004 (Breast Neoplasms...) : Decreased secretion of Cathepsin D in breast cancer in vivo by tamoxifen : mediated by the mannose-6-phosphate/IGF-II receptor ?
Mathieu et al., Mol Endocrinol 1991 (Breast Neoplasms) : Estradiol down-regulates the mannose-6-phosphate/insulin-like growth factor-II receptor gene and induces cathepsin-D in breast cancer cells : a receptor saturation mechanism to increase the secretion of lysosomal proenzymes